| 引用本文: | 范高福,刘修树,汤洁,龚菊梅,蔡玉华.正交设计石榴鞣花酸凝胶剂处方配比的研究[J].中国现代应用药学,2016,33(12):1523-1525. |
| FAN Gaofu,LIU Xiushu,TANG jie,GONG Jumei,CAI Yuhua.Prescription Ratio of Pomegranate Ellagic Acid Gel by Orthogonal Design[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(12):1523-1525. |
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| 摘要: |
| 目的 采用正交设计法对石榴中鞣花酸凝胶处方配比进行优化。方法 采用正交分析法，以丙二醇、卡波姆-940以及凝胶pH水平作为影响因素，以凝胶剂的外观形状、涂展性、均匀性以及离心性作为考察指标，筛选出最优处方配比。结果 1.5%卡波姆-940、15%丙二醇以及控制凝胶pH在4.0~5.0内其各项指标达到最优。结论 经过正交设计优化后的凝胶剂其工艺方法简单且稳定可靠，具有生产可行性。 |
| 关键词: 石榴 鞣花酸 凝胶剂 正交设计 |
| DOI：10.13748/j.cnki.issn1007-7693.2016.12.008 |
| 分类号: |
| 基金项目:安徽省教育厅高校自然科学研究项目（KJ2015A440，KJ2016A616，KJ2016A613）；安徽省教育厅质量工程项目（2014sxzx047） |
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| Prescription Ratio of Pomegranate Ellagic Acid Gel by Orthogonal Design |
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FAN Gaofu, LIU Xiushu, TANG jie, GONG Jumei, CAI Yuhua
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Department of Biotechnology Applications, Hefei Technology College, Hefei 238000, China
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| Abstract: |
| OBJECTIVE To optimize prescription ratio of pomegranate ellagic acid gel by orthogonal design. METHODS Using orthogonal design, propylene glycol, carbomer-940 and gel pH level as influencing factors, the appearance, spread stretchability, uniformity and centrifugal were used as index, which was taken to selected for the optimum formula. RESULTS The indicators achieved optimal with 1.5% Carbopol-940, 15% propylene glycol and gel pH in the range of 4.0~5.0. CONCLUSION After the orthogonal design, the optimized method is simple, stable and reliable, and has the feasibility of production. |
| Key words: pomegranate ellagic acid gel orthogonal design |
