基于炎症环境的口服结肠靶向给药系统研究进展

Advances in Oral Colon Targeted Drug Delivery System Based on Inflammation

关键词:  结肠靶向给药系统  口服给药  纳米技术  炎症性肠病

Key words:  colon targeted drug delivery system  oral administration  nanotechnology  inflammatory bowel disease

摘要:

口服结肠靶向给药系统由于能改善结肠局部疾病的治疗效果和降低不良反应而成为该领域的研究热点。口服给药系统设计方法的不断发展显著提高了药物在结肠部位的生物利用度，然而，要使药物在发病期能够发挥治疗效果，还须关注到结肠炎症时胃肠道出现生理条件变化的影响。纳米技术已经作为提高药物在结肠炎症病灶区摄取的新策略而应用于口服剂型设计中，本文主要介绍该纳米给药系统的设计方法和研究进展。

Abstract:

Oral colon targeted drug delivery is an active area of research for local diseases affecting the colon, as it improves the efficacy of therapeutics and reduces systemic toxicity. Advances in oral drug delivery design have significantly improved the bioavailability of drugs to the colon; however in order to have therapeutic efficacy for a drug during disease, considerations must be made for the altered physiology of the gastrointestinal (GI) tract that is associated with GI inflammation. Nanotechnology has been used in oral dosage formulation design as strategies to further enhance uptake into diseased tissue within the colon. This review will summarize the major design methods of nano-delivery systems and the research progress.