| 摘要: |
| 活性氧（reactive oxygen species，ROS）是机体氧化应激时产生的主要分子，可造成DNA损伤和基因不稳定，与多种器官损害和肿瘤发生发展等密切相关。近年来，利用正常细胞与肿瘤细胞内ROS水平的差异，设计ROS响应性纳米给药系统，使其在肿瘤高ROS环境下释放药物，可提高药物的靶向性和疗效，本文将对该领域的最新进展进行概述。 |
| 关键词: 活性氧 肿瘤 纳米给药系统 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.05.032 |
| 分类号: |
| 基金项目:国家自然科学基金项目（81373346，81673022） |
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| Progress in ROS Sensitive Nano-drug Delivery System |
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GUO Wangwei, HAN Min
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College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| Reactive oxygen species(ROS) mainly produced by oxidative stress, not only causes DNA damage and genetic unstability, but also closely involves in organ lesion and tumor development. Recently, taking advantage of ROS difference between the normal cells and tumor cells, ROS responsive nano-delivery system is designed. Drugs only release within the tumor micro-environment at high level of ROS, which ensures high selectivity and therapeutic efficacy. The newly progress made in this field will be briefly discussed in this paper. |
| Key words: reactive oxygen species (ROS) tumor nano-drug delivery system |
