温敏聚合物自组装纳米粒子在抗肿瘤药物递送中的应用

Nanoparticles Self-assembled by Thermoresponsive Polymers for Anticancer Drug Delivery

关键词:  温敏聚合物  自组装  胶束  囊泡  药物递送  抗肿瘤

Key words:  thermoresponsive polymer  self-assemble  micelle  polymersome  drug delivery  anticancer

摘要:

作为抗肿瘤治疗的主要手段，化疗最大的缺陷在于化疗药物缺乏肿瘤靶向性，易对正常组织产生高毒性，并导致治疗效果不理想。为解决这一问题，越来越多的聚合物纳米载体被用于递送抗肿瘤药物，包括对温度刺激能作出响应的温敏聚合物自组装纳米载体。本文综述了近年来温敏聚合物自组装载体及其纳米粒子的研究进展，并介绍了其在抗肿瘤药物递送中的应用。

Abstract:

As one of the main means for cancer therapy, the biggest drawback of chemotherapy is that most of chemotherapeutics can't target tumor, resulting in high toxicity to normal tissues and unsatisfied treatment effect. In order to overcome this problem, a growing number of polymeric nanocarriers have been studied to deliver antineoplastic drugs, including those self-assembled to nanoparticles showing a change in physic-chemical properties in response to a temperature stimulus. This paper summarize the recent research progress of thermoresponsive polymers and their self-assembled nanoparticles, and introduce their application in anticancer drug delivery.