多黏菌素B局部给药治疗泛耐药鲍曼不动杆菌神经系统感染

Effect of Using Polymyxin B by Local Medication on Xdr-Acinetobacter Baumannii Infections of the Nervous System

关键词:  多黏菌素B  泛耐药  鲍曼不动杆菌  神经系统感染  临床药师

Key words:  polymyxin B  XDR  Acinetobacter baumannii  nervous system infection  clinical pharmacists

摘要:

目的 探讨泛耐药鲍曼不动杆菌神经系统感染的治疗策略。方法 结合临床药师亲身参与的1例泛耐药鲍曼不动杆菌神经系统感染的治疗，介绍多黏菌素B在治疗中的合理应用。结果 临床药师推荐通过多黏菌素B局部给药方式，加强局部组织药物浓度，提高泛耐药鲍曼不动杆菌治疗效果。同时，在多黏菌素B的应用剂量、途径、监护等多方面提供了合理建议。患者感染最终得以控制，未出现肾毒性和神经毒性反应。结论 多黏菌素B的局部用药为泛耐药鲍曼不动杆菌神经系统感染治疗提供了新思路。

Abstract:

OBJECTIVE To discuss extensively drug resistant(XDR)-Acinetobacter baumannii infection treatment strategy of the nervous system. METHODS Combining with a case of XDR-Acinetobacter baumannii therapy of nervous system infection, to introduce reasonable application of polymyxin B. RESULTS According to the consensus, the clinical pharmacist recommended to use polymyxin B by local medication to strengthen the local tissue drug concentration and improve the effect of XDR-Acinetobacter baumannii treatment. At the same time, the clinical pharmacist provided the reasonable suggestions in many aspects, such as in the application of polymyxin B dosage, ways, monitoring and so on for clinician. In the end, the infection was under control without renal toxicity and nerve toxicity reaction. CONCLUSION Using polymyxin B by local medication provides a new way of thinking of XDR-Acinetobacter baumannii infections of the nervous system.