党参超微粉对胃溃疡模型大鼠胃黏膜保护作用的研究

Protective Effects of Codonopsis Radix on Gastric Mucosa in Rats with Gastric Ulcer

关键词:  党参  超微粉  胃溃疡  胃泌素  前列腺素  表皮生长因子

Key words:  Codonopsis Radix  ultra-fine powder  gastric ulcer  gastrin  6-keto-PGF1α  epidermal growth factor

摘要:

目的 研究比较党参超微粉与普通粉对胃溃疡大鼠胃黏膜损伤的保护作用。方法 制备乙酸致胃黏膜损伤型大鼠胃溃疡模型，经2种粉末治疗10 d后，测定溃疡面积，计算溃疡指数；分别用放射免疫法检测各组大鼠血清中胃泌素（gastrin，Gas）及血浆中6-keto-PGF1α含量，并采用酶联免疫法测定血清中表皮生长因子（EGF）含量。结果 2组大鼠溃疡指数均低于模型组，且超微粉组明显低于普通粉组；超微粉组大鼠血清Gas含量低于普通粉组，6-keto-PGF1α和EGF含量高于普通粉组。结论 党参超微粉对胃溃疡的疗效优于普通粉，超微粉碎有助于提高党参药效。

Abstract:

OBJECTIVE To compare the protective effect of ultramicro-powder and powder of Codonopsis Radix on gastric mucosa of gastric ulcer in rats. METHODS The model of gastric ulcer were set up by acetic acid, after treated by the two kinds of powder for 10 d, to measure the gastric ulcer area and count out the inhibitory rate. The levels of gastrin and 6-keto-PGF1α were measured by radioimmunity, EGF were measured by ELISA method. RESULTS Ulcer index of the ultramicro-powder group and powder group were lower than that of model group, and it in the ultramicro-powder group was lower than the powder group. The levels of gastrin in ultramicro-powder group were obviously lower than that in powder group, while the levels of 6-keto-PGF1α and EGF in ultramicro-powder group were obviously higher than that in powder group. CONCLUSION The therapeutic effect on gastric mucosa damage of ultramicro-powder of Codonopsis Radix is superior to the powder. The efficacy of Codonopsis Radix can be improved by superfine comminution.