| 引用本文: | 谢智奇,皇甫铭一,韩旻.肿瘤微环境MMP酶响应性纳米给药系统研究进展[J].中国现代应用药学,2017,34(6):903-906. |
| XIE Zhiqi,HUANGFU Mingyi,HAN Min.MMP Enzyme in Tumor Micro-environment:A Promising Target for Nano-medicine Delivery[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(6):903-906. |
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| 摘要: |
| 肿瘤靶向纳米制剂的研究是近些年医药领域内的研究热点之一。其中，肿瘤微环境在肿瘤增殖、侵袭和转移中发挥关键性作用，肿瘤微环境响应性纳米制剂的研究日益受到关注。研究发现，以基质金属蛋白酶（matrix metalloproteinase，MMP）为代表的酶类在多种肿瘤微环境中高度表达，其底物可被设计应用于药物传递及成像系统，并显示出了对肿瘤微环境内MMP的高度响应。本文对肿瘤微环境内以MMP为代表的高表达酶为靶点的纳米给药系统的研究进展作一概述。 |
| 关键词: 肿瘤微环境 基质金属蛋白酶 酶响应性 纳米给药系统 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.06.027 |
| 分类号: |
| 基金项目:国家自然科学基金资助项目（81373346，81673022） |
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| MMP Enzyme in Tumor Micro-environment:A Promising Target for Nano-medicine Delivery |
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XIE Zhiqi, HUANGFU Mingyi, HAN Min
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College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| Recently, plenty of researches have been done on the tumor targeting nano-medicines. As the study on tumor progression, invasion and metastasis deepens, tumor micro-environment responsive nano-preparations become an issue of increasing concern. Enzymes represented by matrix metalloproteinase(MMP) are highly expressed within the tumor micro-environment. Therefore, its substance can be designed for drug delivery and imaging. In this review, nano-delivery system responding to MMP and other highly expressed enzymes are generally introduced. |
| Key words: tumor micro-environment MMP enzyme responsive nanomedicine delivery system |
