| 引用本文: | 陈晓红,迟宗良,秦昆明,蔡宝昌.姜黄素-赖氨酸共晶在无水乙醇中的热力学研究[J].中国现代应用药学,2017,34(6):871-875. |
| CHEN Xiaohong,CHI Zongliang,QIN Kunming,CAI Baochang.thermodynamics of curcumin-lysine cocrystal in anhydrous ethanol[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(6):871-875. |
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| 姜黄素-赖氨酸共晶在无水乙醇中的热力学研究 |
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陈晓红1,2, 迟宗良2,3, 秦昆明3, 蔡宝昌3,4
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1.杭州市萧山区第一人民医院, 杭州 311200;2.浙江中医药大学, 杭州 310053;3.南京海昌中药集团有限公司, 南京 210044;4.江苏省中药炮制重点实验室, 南京 210049
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| 摘要: |
| 目的 考察在三元体系中各条件下的平衡状态，计算姜黄素共晶的相关热力学常数，探讨无水乙醇作为特异性溶剂的合理性。方法 采用溶液法分别测定姜黄素在不同温度下、不同浓度赖氨酸的无水乙醇中的溶解度，通过数学推导，得出姜黄素共晶的热力学常数。结果 绘制了姜黄素-赖氨酸-无水乙醇的三元相图，并求得了Ksp、Kll、△G°、△H及△S等热力学参数。结论 无水乙醇可以作为特异性溶剂用于提取姜黄素共晶中混杂的姜黄素单体。 |
| 关键词: 姜黄素-赖氨酸共晶 无水乙醇 热力学 特异性溶剂 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.06.019 |
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| 基金项目:江苏省自然科学基金（BK20141094） |
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| thermodynamics of curcumin-lysine cocrystal in anhydrous ethanol |
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CHEN Xiaohong1,2, CHI Zongliang2,3, QIN Kunming3, CAI Baochang3,4
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1.Hangzhou Xiaoshan First People's Hospital, Hangzhou 311200, China;2.Zhejiang Chinese medical University, Hangzhou 310053, China;3.Nanjing Haichang Chinese Medicine Group Co., Ltd., Nanjing 210044, China;4.Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing 210049, China
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| Abstract: |
| OBJECTIVE To calculate the thermodynamic constant of a ternary systerm made up with curcumin, lysine and anhydrous ethanol at different temperatures with different ratio. Moreover, to discuss the rationality of anhydrous ethanol as a specific solvent. METHODS Determine the solubility of curcumin in different concentration of lysine solutions at different temperature, and get the thermodynamic constants by calculating. RESULTS The ternary phase diagrams were graphed; Ksp, Kll, △G°, △H and △S were calculated. CONCLUSION Anhydrous ethanol could be used as a specific solvent to extract curcumin monomer mixed in curcumin-lysine cocrystal. |
| Key words: curcumin-lysine cocrystal anhydrous ethanol thermodynamics specific solvent |
