NL-101-羟丙基倍他环糊精包合物的制备及其特性研究

Study on the Preparation of NL-101-hydroxypropylbetadex Inclusion Complex and its Characteristic

关键词:  NL-101  羟丙基倍他环糊精  包合  包合率  冷冻干燥

Key words:  NL-101  NL-101-hydroxypropylbetadex  inclusion complex  inclusion ratio  freeze drying

摘要:

目的 考察NL-101-羟丙基倍他环糊精包合物的制备方法。方法 采用冷冻干燥法制备NL-101-羟丙基倍他环糊精包合物，以NL-101包合率为指标，通过正交试验优化包合条件。结果 优化的工艺条件为搅拌速度100 r·min^-1，搅拌温度10℃，搅拌时间30 min，NL-101：羟丙基倍他环糊精摩尔比为1：10，按此条件采用冷冻干燥法制备NL-101-羟丙基倍他环糊精包合物，采用X衍射分析和红外光谱法进行确认，表明冷冻干燥后得到了包合物。结论 NL-101与羟丙基倍他环糊精通过冷冻干燥法可形成包合物，按此工艺条件，NL-101-羟丙基倍他环糊精包合物的包合率>95%，同时包合物可提高NL-101的溶解度。

Abstract:

OBJECTIVE To study the preparation of NL-101-hydroxypropyl betacyclodextrin inclusion complex. METHODS The NL-101-hydroxypropylbetadex inclusion complex was prepared by freeze drying method and was optimized with inclusion ratio as index by orthogonal experiment. RESULTS The optimized conditions were 100 r·min^-1 of stirring speed, 10℃ of stirring temperature, 30 min of stirring time, 1:10 of ratio of NL-101:hydroxypropyl betacyclodextrin confirmed by X-ray diffraction method and infrared spectroscopy. CONCLUSION NL-101-hydroxypropylbetadex inclusion complex can be effectively prepared with freeze drying method. And the inclusion with greater than 95% of the inclusion ratio is prepared. The solubility of NL-101 is increased when the durg was included by hydroxypropyl betacyclodextrin.