| 引用本文: | 楼江,林能明,刘占利,王刚,王飞,李晴宇,陈玲,严伟.拉莫三嗪代谢酶和转运体基因多态性对血药浓度的影响的研究进展[J].中国现代应用药学,2017,34(12):1774-1778. |
| LOU Jiang,LIN Nengming,LIU Zhanli,WANG Gang,WANG Fei,LI Qingyu,CHEN Ling,YAN Weia.Research progress of the Effects of Polymorphic Metabolic Enzymes and Transporters on Lamotrigine Concentrations[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(12):1774-1778. |
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| 拉莫三嗪代谢酶和转运体基因多态性对血药浓度的影响的研究进展 |
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楼江1, 林能明1, 刘占利2, 王刚1, 王飞1, 李晴宇1, 陈玲1, 严伟1
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1.杭州市第一人民医院药学部, 杭州 310006;2.杭州市第一人民医院儿科, 杭州 310006
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| 摘要: |
| 拉莫三嗪是一线抗癫痫药物，临床疗效和不良反应个体差异大与血药浓度有关，近年来寻找拉莫三嗪血药浓度差异的原因是研究的热点。本综述探讨了代谢酶和转运体基因多态性对拉莫三嗪血药浓度的影响，以期为拉莫三嗪个体化治疗提供参考依据。 |
| 关键词: 拉莫三嗪 代谢酶 转运体 基因多态性 血药浓度 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.12.029 |
| 分类号:R969.1 |
| 基金项目:浙江省药学会医院药学专项科研自助基金（2016ZYY14）；浙江省医药卫生科技计划项目（2018RC061） |
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| Research progress of the Effects of Polymorphic Metabolic Enzymes and Transporters on Lamotrigine Concentrations |
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LOU Jiang1, LIN Nengming1, LIU Zhanli2, WANG Gang1, WANG Fei1, LI Qingyu1, CHEN Ling1, YAN Weia1
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1.First people's Hospital of Hangzhou, Department of Pharmacy, Hangzhou 310006, China;2.First people's Hospital of Hangzhou, Department of Pediatrics, Hangzhou 310006, China
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| Abstract: |
| Lamotrigine is used as a first-line therapeutic agent for the treatment of epilepsy. Large interindividual variability in clinical efficacy and adverse reactions of lamotrigine has been observed, it maybe associated with lamotrigine serum concentration. Recently, to search the variability has become a research focus in lamotrigine serum concentration. Through access to the domestic and foreign references in this paper, to investigate the effects of polymorphic metabolic enzymes and transporters on lamotrigine concentraions, and hope to provide reference for the individualized treatment of lamotrigine. |
| Key words: lamotrigine metabolic enzyme transporter single nucleoside polymorphisms plasma concentration |
