谷胱甘肽防治疾病的研究进展

Research Progress of Glutathione in the Prevention and Treatment of Diseases

关键词:  谷胱甘肽  应用  进展  疾病

Key words:  glutathione  application  progress  disease

摘要:

谷胱甘肽是由谷氨酸、半胱氨酸及甘氨酸组成的三肽，具有保护细胞、抗氧化、抗衰老、解毒等作用，几乎存在于人体每个细胞中。虽然谷胱甘肽已经是治疗某些疾病的临床常用药，但近年来的研究显示体内谷胱甘肽水平及其还原型和氧化型2种形式比例的改变与运动、神经、内分泌、循环、呼吸、消化、泌尿、生殖等系统疾病相关。本文总结了近6年来谷胱甘肽在细胞和动物试验及临床研究的最新进展，为谷胱甘肽老药新用研究开发及临床用药提供参考。

Abstract:

Glutathione is a tripeptide composed of glutamic acid, cysteine and glycine, which plays essential roles in cell-protection, anti-oxidation, anti-aging, detoxification, etc. Glutathione almost exists in every cell of the human body. As a common clinical medicine, it is used for treating several kinds of diseases. Recent studies have shown that the changes of GSH level and GSH/GSSG proportion are closely related with diseases in locomotor, nervous, endocrine, circulatory, respiratory, digestive, urinary and reproductive systems. The purpose of this review is to summarize the research progress of GSH in the prevention and treatment of diseases based on cell and animal experiments as well as clinical researches in recent six years so as to provide references for new drug development and clinical applications of glutathione.