引用本文: | 周思宇,谢作都,叶添宝,张瑶,王菡潇,刘佃花,肖泽宇.5-氨基水杨酸的结肠靶向释药系统[J].中国现代应用药学,2017,34(8):1205-1210. |
| ZHOU Siyu,XIE Zuodu,YE Tianbao,ZHANG Yao,WANG Hanxiao,LIU Dianhua,XIAO Zeyu.Colon-targeted Drug Delivery Systems for 5-Aminosalicylic Acid[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(8):1205-1210. |
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5-氨基水杨酸的结肠靶向释药系统 |
周思宇1, 谢作都1, 叶添宝1, 张瑶1, 王菡潇1, 刘佃花1,2, 肖泽宇1,2
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1.上海交通大学医学院, 基础医学院, 上海 200025;2.上海交通大学医学院, 协同创新中心, 上海 200025
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摘要: |
5-氨基水杨酸是目前治疗炎症性肠病(inflammatory bowel disease,IBD)的首选药物,但因其口服后主要被小肠吸收,导致结肠局部浓度低而降低药效。结肠靶向给药系统可以使药物直达病变部位,提高药效,因而成为研究热点。本文就几种结肠靶向给药系统进行讨论,以望为日后IBD治疗的研究提供参考。 |
关键词: 5-氨基水杨酸 炎症性肠病 结肠靶向给药系统 |
DOI:10.13748/j.cnki.issn1007-7693.2017.08.031 |
分类号:R915 |
基金项目:国家自然科学基金资助(81471779,31671003) |
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Colon-targeted Drug Delivery Systems for 5-Aminosalicylic Acid |
ZHOU Siyu1, XIE Zuodu1, YE Tianbao1, ZHANG Yao1, WANG Hanxiao1, LIU Dianhua1,2, XIAO Zeyu1,2
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1.Shanghai Jiao Tong University School of Medicine, School of Basic Medicine, Shanghai 200025, China;2.Shanghai Jiao Tong University School of Medicine, Collaborative Innovation Center, Shanghai 200025, China
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Abstract: |
5-aminosalicylic acid(5-ASA) is the primary drug candidate for the treatment of inflammatory bowel disease(IBD); However, its targeted efficacy in colon site is limited as majority of the drug is absorbed by small intestine after oral administration. As such, great interest is focusing on the design of colon-targeted drug delivery systems to deliver drugs at targeted site, thus enhancing therapeutic efficacy. This paper summarize recent progress in the development of colon-targeted drug delivery systems for 5-ASA, aiming at providing valuable information for IBD treatment. |
Key words: 5-aminosalicylic acid inflammatory bowel disease colon-targeted drug delivery systems |