| 引用本文: | 李鑫,郭凌阁,邓蕾,冮怡琳,张琦,赵莹莹.硝苯地平自微乳的性能研究[J].中国现代应用药学,2017,34(11):1576-1581. |
| LI Xin,GUO Lingge,DENG Lei,GANG Yilin,ZHANG Qi,ZHAO Yingying.Study on the Synthesis and Properties of Nifedipine Self Microemulsion System[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(11):1576-1581. |
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| 摘要: |
| 目的 将硝苯地平制备成微乳，以提高其生物利用度。方法 利用透射电镜以及Zeta电位测定仪等技术检测硝苯地平自微乳的平均粒径及粒径分布、形态特征、表面电位、稳定性、药物的体外释放以及体内的吸收等特点，并进行初步质量评价研究。结果 所制得的硝苯地平自微乳平均粒径为25~26 nm，分布较为集中；粒子形态圆整，大小均匀；表面电位为-（25.1±1.1） mV；体外释放度>90%。结论 将硝苯地平制成自微乳，药物在体内有良好的吸收。 |
| 关键词: 硝苯地平 自微乳 质量评价 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.11.017 |
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| Study on the Synthesis and Properties of Nifedipine Self Microemulsion System |
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LI Xin, GUO Lingge, DENG Lei, GANG Yilin, ZHANG Qi, ZHAO Yingying
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Harbin University of Commerce college of pharmacy, Harbin 150076, China
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| Abstract: |
| OBJECTIVE To improve the bioavailability of nifedipine by the preparation of micro-emulsified. METHODS Using transmission electron microscope and Zeta potential analyzer for the average particle of nifedipine self microemulsion size and particle size distribution, morphological characteristics, surface potential, stability, release in vitro and absorption in vivo characteristics of initial quality evaluation. RESULTS The average diameter size of nifedipine self-emulsion was 25~26 nm. The average particle the distribution was more concentrated; particle shape, uniform size; surface potential was -(25.1+1.1)mV; the in vitro release rate was >90%. CONCLUSION The drug has made nifedipine self-emulsion which has good absorption in vivo. |
| Key words: nifedipine self-emulsion quality evaluation |
