冰片对黄芪甲苷体内吸收的促进作用

Promoting effects of Borneol on the Absorption of Astragaloside Ⅳ in vivo

关键词:  冰片  黄芪甲苷  体内吸收  肠循环

Key words:  borneol  astragaloside Ⅳ  in vivo absorption  intestinal circulation

摘要:

目的 研究黄芪甲苷配伍冰片前后在大鼠小肠的吸收情况。方法 采用大鼠原位肠循环灌注实验法研究黄芪甲苷配伍冰片前后体内吸收动力学的具体变化。结果 黄芪甲苷在5~20 mg·kg^-1内的吸收动力学参数无显著性差异；2.5 mg·kg^-1冰片与黄芪甲苷配伍前后的动力学参数无显著性差异，而5，10 mg·kg^-1冰片配伍前后有显著性差异（P<0.01），但5，10 mg·kg^-1剂量组之间的动力学参数差异不显著。结论 冰片在一定的剂量范围内可促进黄芪甲苷在大鼠小肠内的吸收，可与黄芪甲苷配伍应用以提高生物利用度。

Abstract:

OBJECTIVE To study the absorption of astragaloside Ⅳ in the small intestine before and after the combination application of borneol. METHODS The changes of absorption kinetics of astragaloside Ⅳ inoculated with borneol were studied by in situ intestinal perfusion in rats. RESULTS There was no significant difference in the absorption kinetics parameters of astragaloside Ⅳ in the concentration range of 5~20 mg·kg^-1. There was also no significant difference in the kinetics parameters between astragaloside Ⅳ and astragaloside Ⅳ combined with 2.5 mg·kg^-1 borneol. While there was significant difference of absorption kinetics before and after being combined with 5 mg·kg^-1 and 10 mg·kg^-1 borneol(P<0.01). But there was no significant difference in the kinetic parameters between 5 mg·kg^-1 and 10 mg·kg^-1borneol group. CONCLUSION Borneol can promote the absorption of astragaloside Ⅳ in the small intestine in a certain dose range. It can be used in combination with astragaloside Ⅳ to improve the bioavailability.