宣氏清解汤治疗小儿化脓性扁桃体炎的疗效评价

Therapeutic evaluation of Xuan's Qingjie Decoction on Acute Purulent Tonsillitis in Children

关键词:  宣氏清解汤  急性化脓性扁桃体炎  中西医结合  临床研究

Key words:  Xuan's Qingjie Decoction  acute purulent tonsillitis  combination of Chinese traditional and Western medicine  clinical study

摘要:

目的 观察宣氏清解汤治疗小儿化脓性扁桃体炎的临床疗效。方法 采用随机对照法收集60例确诊为急性化脓性扁桃体炎的患儿，分为常规组（阿莫西林/克拉维酸钾抗感染治疗）和联合组（阿莫西林/克拉维酸钾抗感染联合宣氏清解汤治疗）。5 d 1个疗程后计算主次症积分、总积分及总积分下降率，主要症状体征改善时间和实验室指标变化作为疗效判定标准。结果 常规组与联合组在治疗后的主、次症积分和总积分均较治疗前明显下降（P<0.05），联合组在降低主、次症积分和总积分方面更优于常规组（P<0.05）。联合组的退热、咽痛缓解、扁桃体缩小和扁桃体充血缓解时间均较常规组更短（P<0.05）。常规组与联合组在治疗后的感染指标WBC和CRP水平均较治疗前明显下降，但2组间比较差异无统计学意义。常规组治愈率为6.67%，总有效率为90.00%；联合组治愈率为30.00%，总有效率为96.67%；2组相比，联合组的治愈率优于常规组（P<0.05）。结论 宣氏清解汤辅助常规抗菌药物治疗能更有效、快速地改善急性化脓性扁桃体炎患儿的临床症状和体征，显著控制感染水平，从而显出良好的临床疗效，值得临床推广应用。

Abstract:

OBJECTIVE To observe the clinical therapeutic efficacy of Xuan's Qingjie Decoction on acute purulent tonsillitis in children. METHODS Using randomized, controlled clinical research method, 60 cases that met the acute purulent tonsillitis were selected and then divided randomly into regular therapy group (which was infused the injectable Amoxycillin/Clavulanate Potassium) and combined therapy group (which was treated with Xuan's Qingjie Decoction and infused the injectable Amoxycillin/Clavulanate Potassium). After a five days' therapy course, the scale of decrease of primary symptom scores, secondary symptom scores and total scores, the main symptoms and signs improvement time, as well as the changes of laboratory indexes as criterion for effectiveness were calculated. RESULTS The primary symptom scores, secondary symptom scores and total scores in both two groups after treatment were declined markedly when compared with those before treatment (P<0.05), while the downward trend in combined therapy group was more obvious (P<0.05). The time of fever clearance, sore throat relieving, tonsil atrophying and congestion mitigating in combined therapy group were all shorter than those in regular therapy group (P<0.05). The expression level of infectious indicators such as WBC and CRP in both two groups after treatment were declined markedly when compared with those before treatment (P<0.05), while the difference of the downward trend of WBC and CRP between two groups was not statistically significant. The cure rate was 6.67%, and the total effective rate was 90.00% in regular therapy group, while the cure rate was 30.00%, and the total effective rate was 96.67% in combined therapy group. The overall curative effect in combined therapy group was superior to regular therapy group (P<0.05). CONCLUSION The use of Xuan's Qingjie Decoction on the basis of regular antibiotic therapy can improve the clinical symptoms and physical signs of children with acute purulent tonsillitis more efficiently and more quickly, and can control the infectious level significantly, thus showing a good clinical curative effect, which is worth of promotion.