复方甘草酸苷联合阿昔洛韦治疗带状疱疹的随机对照试验Meta分析

Treatment of Herpes Zoster by Compound Glycyrrhizin Combined with Acyclovir:A Meta-analysis of Randomized Controlled Trail

关键词:  复方甘草酸苷  阿昔洛韦  带状疱疹  随机对照试验  Meta分析

Key words:  compound glycyrrhizin  acyclovir  herpes zoster  randomized controlled trial  meta analysis

摘要:

目的 评价复方甘草酸苷联合阿昔洛韦治疗带状疱疹的有效性和安全性。方法 检索CNKI、万方、维普数据库及PubMed、The Cochrane Library关于复方甘草酸苷联合阿昔洛韦治疗带状疱疹的随机对照试验（RCT）。结果 分析共纳入23个RCT，涉及1 669例带状疱疹患者。复方甘草酸苷联合阿昔洛韦治疗带状疱疹在治疗总有效率、疼痛缓解时间、止痛时间、结痂时间、止疱时间、痊愈时间和后遗神经痛发生情况等指标方面均明显优于单用阿昔洛韦治疗。结论 复方甘草酸苷联合阿昔洛韦治疗带状疱疹的总体疗效优于单用阿昔洛韦，但由于研究存在一定的局限性，研究结果仍需要更多的多中心、大样本、双盲的高质量RCT支持。

Abstract:

OBJECTIVE To evaluate the efficacy and safety of compound glycyrrhizin combined with aciclovir in the treatment of herpes zoster. METHODS Randomized controlled trials (RCTs) of compound glycyrrhizin combined with acyclovir in the treatment of herpes zoster were retrospectively analyzed by CNKI, Wanfang Database, VIP Database and PubMed, The Cochrane Library. RESULTS A total of 23 RCTs involving 1 669 patients with herpes zoster were included. The efficacy of compound glycyrrhizin combined with aciclovir in the treatment of herpes zoster in total effective rate, pain relief time, analgesic time, crusting time, blister time, recovery time and the occurrence of postherpetic neuralgia were significantly better than single acyclovir treatment. CONCLUSION The overall efficacy of compound glycyrrhizin combined with acyclovir in the treatment of herpes zoster is superior to acyclovir alone, but results still need to be supported by more high-quality RCTs of multi-center, large sample, double-blind.