| 引用本文: | 崔华清,殷菲.淀粉样前体蛋白修饰、转运及其剪切加工研究进展[J].中国现代应用药学,2018,35(3):444-447. |
| Cui Huaqing,Yin Fei.Advance of Modification, Trafficking and Processing of Amyloid Precursor Protein[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(3):444-447. |
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| 摘要: |
| 阿尔茨海默病（Alzheimer disease，AD）是一种常见的神经系统退行性疾病，其患病率随着年龄的增加而升高。越来越多的研究结果表明，淀粉样蛋白前体蛋白（amyloid precursor protein，APP）经β-，γ-分泌酶切割产生β淀粉样蛋白（β-amyloid，Aβ）的代谢过程异常是AD形成的主要原因。近年来，人们对APP的修饰及加工过程进行了大量的研究，取得了重要的进展，为AD的防治提供了新的靶点和思路。本文就有关APP修饰及剪切加工的研究进展做一综述。 |
| 关键词: 阿尔茨海默病 淀粉样前体蛋白 修饰 加工 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.03.032 |
| 分类号:R963 |
| 基金项目:重庆市杰出青年项目（cstc2014jcyjjq10003）；重庆高校创新团队建设项目（CXTDX201601031） |
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| Advance of Modification, Trafficking and Processing of Amyloid Precursor Protein |
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Cui Huaqing, Yin Fei
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Chongqing University of Technology, Chongqing Key Lab of Medicinal Chemistry & Molecular Pharmacology, Chongqing 400054, China
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| Abstract: |
| Alzheimer's disease(AD), the most common cause of dementia, is an irreversible, progressive brain disorder. The greatest risk factor is increasing age. An impressive number of references showed that the aggregation and deposit of β-amyloid(Aβ) produced from amyloid precursor protein(APP) were the major cause of the development of AD. Although the resource and mechanisms of AD development need to be explored, there are some progresses on the modification, trafficking, sorting and degradation of APP in recently years. Here, APP modification, trafficking and processing in vitro and in vivo was summarized. |
| Key words: Alzheimer disease amyloid precursor protein modification processing |
