妊娠期女性抗癫痫药物研究进展与药学监护

Researsh Progress of Antiepileptic Drugs in Pregnant Women and Pharmaceutical Care

关键词:  妊娠期  癫痫  抗癫痫药物  致畸性  药学监护

Key words:  pregnancy  epilepsy  antiepileptic drugs  teratogenic risk  pharmaceutical care

摘要:

育龄期女性癫痫患者，在接受抗癫痫治疗的同时，将面临一系列重要的生育健康问题。首先，疾病本身及药物治疗可能影响女性的生殖激素分泌，从而导致患者受孕能力下降。第二，抗癫痫药物（antiepileptic drugs，AEDs）对胎儿有致畸风险；第三，妊娠期癫痫发作将增加母亲死亡率及产科并发症的发生率。本文对近年来国内外关于妊娠期女性抗癫痫管理系列问题的研究进展进行阐述。

Abstract:

Women with epilepsy of childbearing age, when receiving anti epileptic treatment, will be confronted with a series of important reproductive health problems. First, the disease and drug treatment may affect the female reproductive hormone secretion, resulting in decreased ability to conceive. Second, antiepileptic drugs have teratogenic risks to the fetus; Third, seizures in pregnancy will increase maternal mortality and obstetric complications. This paper will focus on the research progress of the anti epileptic management of pregnant women in recent years.