| 引用本文: | 任锦,梁良,周瑜,姜登钊,张丽芳,余敬谋.基于层状双氢氧化物纳米材料的癌症诊断与治疗应用进展[J].中国现代应用药学,2018,35(5):774-780. |
| REN Jin,LIANG Liang,ZHOU Yu,JIANG Dengzhao,ZHANG Lifang,YU Jinmou.Progress in Cancer Diagnosis and Treatment Based on Layered Double Hydroxide Nanomaterials[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(5):774-780. |
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| 摘要: |
| 层状双氢氧化物（layered double hydroxides，LDHs）拥有良好的生物相容性并可自行降解，将其应用于药物递送系统具有独特优势。它的二维空间可以对药物分子进行负载，板层结构和组成可调变，表面带正电荷以及多羟基性质使得LDHs可以通过不同的策略进行改性从而实现多功能化。基于LDHs的多功能纳米材料目前在癌症的诊断和治疗领域具有很好的应用前景。因此，本文从LDHs的靶向药物运输、生物成像以及二者联合方面介绍了LDHs纳米材料在癌症的诊断和治疗方面的应用进展，并分析总结了其生物相容性相关问题及可能的解决方案。 |
| 关键词: 层状双氢氧化物 纳米材料 癌症治疗 诊断 递药系统 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.05.033 |
| 分类号:R965.2 |
| 基金项目:国家自然科学基金项目（81360484） |
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| Progress in Cancer Diagnosis and Treatment Based on Layered Double Hydroxide Nanomaterials |
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REN Jin1, LIANG Liang2, ZHOU Yu1, JIANG Dengzhao1, ZHANG Lifang1, YU Jinmou1
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1.School of Pharmacy and Life Science, Jiujiang University, Jiujiang 332000, China;2.Analytical and Testing Center, Jiujiang University, Jiujiang 332000, China
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| Abstract: |
| Layered double hydroxides(LDHs) with good biocompatibility and self-degradation have unique advantages in drug delivery systems. Drugs can be loaded in two-dimensional space of LDHs. In the meanwhile, it can be modified by different strategies to achieve multifunctional LDHs because of the adjustable variability of its spatial structure and composition, positively charged surface and polyhydroxy property. Multifunctional nanomaterials based on LDHs have a promising application in the field of cancer diagnosis and therapy at present. Therefore, this paper introduced the application of LDHs nanomaterials in the cancer diagnosis and treatment from targeted drug transport, biological imaging and the joint of two aspects, and summarized the biocompatibility problems LDHs faced and the possible solutions. |
| Key words: layered double hydroxides nanomaterials cancer therapy diagnosis drug delivery system |
