| 引用本文: | 薛巧如,陈宇堃,黄丽华,梁蔚阳.原子吸收光谱法测定果糖二磷酸钠制剂中的铝离子含量[J].中国现代应用药学,2018,35(7):971-974. |
| XUE Qiaoru,CHEN Yukun,HUANG Lihua,LIANG Weiyang.Determination of Al in Fructose Sodium Diphosphate for Injection by Atomic Absorption Spectrometry[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(7):971-974. |
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| 摘要: |
| 目的 采用原子吸收光谱法测定国家评价性抽样118批注射用果糖二磷酸钠及果糖二磷酸钠注射液中铝的含量。方法 采用硝酸镁作为基体改进剂，塞曼偏振背景校正的原子吸收光谱法测定果糖二磷酸钠制剂中铝的含量。结果 铝离子在5~30 ng·mL-1内线性关系良好，相关系数为0.998 5，平均回收率为100.1%，RSD为6.7%（n=9）。结论 本方法灵敏、准确，可用于果糖二磷酸钠制剂中铝含量的测定。国内果糖二磷酸钠制剂中铝含量测定结果差异大，产品存在铝含量过高的问题。 |
| 关键词: 原子吸收光谱法 铝 果糖二磷酸钠 含量测定 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.07.005 |
| 分类号:R917 |
| 基金项目:广东省医学科学技术研究基金项目（B2017089） |
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| Determination of Al in Fructose Sodium Diphosphate for Injection by Atomic Absorption Spectrometry |
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XUE Qiaoru, CHEN Yukun, HUANG Lihua, LIANG Weiyang
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Guangdong Institute for Drug Control, Guangzhou 510180, China
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| Abstract: |
| OBJECTIVE To establish a graphite furnace atomic absorption spectrometry method for determination of Al in 118 batchs of Fructose Sodium Diphosphate injection and injection for Fructose Sodium Diphosphate for national evalution sampling. METHODS Magnesium nitrate was adopted as matrix modifier, and the content of Al in fructose sodium diphosphate was determined by atomic absorption spectrometry with polarized Zeeman background correction. RESULTS There was a good linear relationship in the concentration range of 5-30 ng·mL-1(r=0.998 5). The average recovery rate was 100.1%, RSD was 6.7%(n=9). CONCLUSION The method is sensitive and accurate, suitable for determination of Al in Fructose Sodium Diphosphate injection and Injection for Fructose Sodium Diphosphate. The result indicates some of the products vary greatly in Al assay, and the product has high aluminum content. |
| Key words: atomic absorption spectromatry Al fructose sodium diphosphate content determination |
