防己茯苓汤配方颗粒对血栓后综合征患者晚期糖基化终末产物的影响

Effect of Fangji Fuling Decoction Prescription Granules on Advanced Glycation End Products of PTS Patients

关键词:  防己茯苓汤配方颗粒  血栓后综合征  晚期糖基化终末产物

Key words:  Fangji Fuling Decoction prescription granules  post-thrombotic syndrome  advanced glycation end products

摘要:

目的 观察防己茯苓汤配方颗粒对血栓后综合征（post-thrombotic syndrome，PTS）患者临床表现和晚期糖基化终末产物（advanced glycation end products，AGEs）的影响。方法 选取60例PTS患者，按1：1随机数字表法分为试验组和对照组，每组30例。2组患者均给予常规治疗，不行球囊扩张等手术介入治疗，仅服用阿司匹林抗凝药及穿戴医用弹力袜。试验组在此基础上口服防己茯苓汤配方颗粒，每日1剂，bid，分早晚温服；对照组在常规基础治疗上口服脉络疏通丸12 g，tid。比较2组患者治疗前、后病情分级评分及静脉血AGEs水平的变化。结果 治疗后试验组病情分级判定标准评分较治疗前及治疗后对照组均明显降低，差异具有统计学意义（P<0.05），而对照组治疗前、后病情分级判定标准评分差异无统计学意义。试验组Villalta评分及血清AGEs水平均较治疗前及同时间段对照组明显改善（P<0.05），而对照组血清AGEs治疗前后无统计学差异（P>0.05）。试验组出现呕吐症状2例，发生率6.67%，对照组有3例患者出现腹胀，发生率13.33%。结论 防己茯苓汤可以改善PTS患者临床表现，减少AGEs的生成，延缓PTS的发生。

Abstract:

OBJECTIVE To observe the effect of formula granule of Fangji Fuling Decoction on the clinical expressions and advanced glycation end products(AGEs) in patients with post-thrombotic syndrome(PTS). METHODS Sixty patients with PTS were randomly divided into experimental group and control group according to 1:1 random number word, 30 cases in each group. Both groups of patients were given conventional treatment, not balloon expansion such interventional surgical of treatment, only oral aspirin such anticoagulants and wearing medical elastic stockings. On the basis of this, the experimental group was given oral Fangji Fuling Decoction prescription granules one dose per day, twice a day at noon and evening; the control group was given 12 g of oral choroid shutong bolus, three times a day. The score of disease status and the level of AGEs in venous blood were compared between the 2 groups before and after treatment. RESULTS The disease grading decision standard scores of the experimental group were lower than before treatment and concurrent control group, the difference was statistically significant(P<0.05).There was no significant difference in the scores of disease grading decision standard before and after treatment in the control group(P>0.05). The Villalta scores and serum AGEs levels in the experimental group were better than before treatment and concurrent control group, the difference was statistically significant(P<0.05). There was no statistical difference in serum AGEs before and after treatment in the control group(P>0.05). There were 2 cases of vomiting in the experimental group, the incidence rate was 6.67%, and 3 cases in the control group occurred abdominal distension, the incidence was 13.33%. CONCLUSION Fangji Fuling Decoction prescription granules can improve the clinical manifestation of PTS patients, reduce the formation of AGEs and delay the occurrence of PTS.