复方巴旦仁颗粒止咳祛痰作用研究

Study on the Expectorant and Relieving Cough Effects of Compound Badanren Granule

关键词:  复方巴旦仁颗粒  止咳  祛痰

Key words:  Compound Badanren granule  eliminate phlegm  relieve cough

摘要:

目的 通过小鼠止咳和祛痰模型，评价复方巴旦仁颗粒的止咳、祛痰作用。方法 建立小鼠氨水引咳模型、二氧化二硫引咳模型，以及小鼠气管酚红排泌量模型，考察水提工艺和醇提工艺制备的不同剂量复方巴旦仁颗粒对小鼠止咳、祛痰模型的作用。结果 水提工艺和醇提工艺制备的复方巴旦仁颗粒低、中、高剂量均能够显著降低氨水及二氧化硫引起的小鼠咳嗽次数（P<0.01或P<0.05）；水提工艺高剂量组能够显著增加小鼠气管酚红排泌量（P<0.05），醇提工艺低、中、高剂量组均能够显著增加小鼠气管酚红排泌量（P<0.01或P<0.05）。结论 复方巴旦仁颗粒具有明显的的止咳、化痰作用，分别经水提工艺和醇提工艺制备的颗粒止咳、化痰作用没有明显区别。

Abstract:

OBJECTIVE To investigate the expectorant and relieving cough effects of Compound Badanren granule by the ammonia water induced mouse cough model. METHODS To observe the effects of relieving cough and expelling phlegm of Compound Badanren granule with different doses through ammonia water induced cough, sulfur dioxide induced cough and phenol red apophlegmating in mice. RESULTS The frequency of cough inducing by ammonia and sulfur dioxide in mice were significant decreased(P<0.05 or P<0.01) in low, middle and high doses of Compound Badanren granule groups that made by the water extracting technology or ethanol extracting technology. Meanwhile, the phenol red apophlegmating was increased significantly(P<0.05) in high dose group of Compound Badanren granule made by water extracting technology, and it was increased(P<0.05 or P<0.01) in low, middle and high doses of Compound Badanren granule groups that made by the ethanol extracting technology. CONCLUSION The Compound Badanren granule has a confirmed expectorant and relieving cough effects, and there is no significant difference between the ethanol extract and the water extract.