| 引用本文: | 彭继千,陈扬武,陈顺,王泽人.扎那米韦鼻用粉雾剂粉体性质研究[J].中国现代应用药学,2018,35(10):1462-1465. |
| PENG Jiqian,CHEN Yangwu,CHEN Shun,WANG Zeren.Study on Powder Characterization of Zanamivir Nasal Powder[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(10):1462-1465. |
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| 摘要: |
| 目的 考察3种方法制备扎那米韦鼻用粉雾剂粉体的性质。方法 分别采用研磨法、气流粉碎法和喷雾干燥法制备不同粒径扎那米韦的粉体，并与吸入乳糖混合，对混合粉体的粒径、微观形态、流动性、堆密度和吸湿性进行考察。结果 研磨法、喷雾干燥法和气流粉碎法得到的扎那米韦原料粉末粒径依次减小；与乳糖相比，3种混合粉体松密度逐渐减小，振实密度依次增加，流动性仅喷雾干燥略增加，研磨法和气流粉碎法无影响； 3种方式得到的混合粉末均没有明显的吸湿性。结论 研磨筛分法比较适合扎那米韦鼻用粉雾剂的进一步开发。 |
| 关键词: 扎那米韦 鼻用粉雾剂 粉体 粒径 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.10.006 |
| 分类号:R943 |
| 基金项目:深圳市科技计划项目（JSGG20141016145810835） |
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| Study on Powder Characterization of Zanamivir Nasal Powder |
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Peng Jiqian,Chen Yangwu,Chen Shun and Wang Zeren
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Shenzhen HLK Pharmaceuticals, Co. Ltd,Shenzhen HLK Pharmaceuticals, Co. Ltd,Shenzhen HLK Pharmaceuticals, Co. Ltd,Shenzhen HLK Pharmaceuticals, Co. Ltd
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| Abstract: |
| OBJECTIVE To develop zanamivir nasal powder, three powder preparation technologies are evaluated. METHODS Zanamivir powder was prepared by milling, air flow milling or spry drying technologies. Then three zanamivir powder mixed respectively with Inhalac 230, a special type of lactose for inhalation. All of the powder was investigated with particle size, characterization, flowability, density, and hygroscopicity. RESULTS Particle size of zanamivir powder prepared by milling, flow miling and spry drying technologies decreased in turn. Compared to lactose for inhalation, density of three types of mixed powder increased in turn, and no significantly change was found in flowability with miling and flow miling but spry drying. Three types of mixed powder had no significantly hygroscopicity. CONCLUSION Milling technology may be a good choice to develop zanamivir nasal powder. |
| Key words: zanamivir nasal powder powder particle size |
