煎药机不同煎煮模式对痰湿瘀阻型中风病汤剂质量的影响

Effect of Different Decoction Models of Automatic Herb Decoction Machine on the Quality of Stroke Decoction

关键词:  常压两煎  高压密闭  半夏白术天麻汤加减方  含量  染菌数

Key words:  double decocting at non-pressure  high-pressure decocting  modified banxia baizhu tianma recipe  content  bacterial count

摘要:

目的 基于自动煎药机的2种工作模式（常压/高压），比较2种煎药模式下痰湿瘀阻型中风病汤剂质量间的差异，筛选该类处方的适宜煎煮模式。方法 采用全自动煎药机高压密闭和常压两煎模式制备汤剂。以总固体量、主要化合物的含量以及染菌数等为考察指标。主要化合物的含量采用HPLC测定，染菌数以中国药典附录下非无菌产品微生物限度检查方法进行考察。结果 经方差分析发现，常压煎煮制备的汤剂相对密度、总固体量及新橙皮苷含量均显著高于高压煎煮。而2种煎煮模式下各供试品中细菌数均<100个，霉菌和酵母菌数亦<100个。结论 经浸泡常压煎煮更适用于半夏白术天麻加减方的制备，为痰湿瘀阻型中风病汤剂的煎煮提供一定的数据支撑。

Abstract:

OBJECTIVE To compare quality differences between apoplexy decoctions of phlegm-dampness-stasis prepared by different models of automatic decocting machine, such as high-pressure decocting and non-pressurized double decocting, then to optimize the decocting mode and standardize the decocting process. METHODS The decoction was prepared by automatic herb decoction machine with high-pressure and non-pressure. The content of total solids and main compounds, and the bacterial count were studied. Among them, the content of main compounds was determined by HPLC, and the bacterial count was examined by microbial limit test method in appendix of Chinese pharmacopoeia. RESULTS Compared with the high pressure decocting model, the variance analysis showed that there were significant differences in relative density, total solid content and neohespridin. These indexes were all higher in non-pressure decocting condition. The bacterial count, molds and yeasts in each sample were less than 100. CONCLUSION It is more suitable for the modified banxia baizhu tianma recipe by soaking and decocting at non-pressure, so as to provide a certain data support for the decoction of phlegm-dampness-stasis type of apoplexy.