| 引用本文: | 田伟,甄亚钦,高乐,范帅帅,李军山,牛丽颖.野菊花饮片标准汤剂的研究[J].中国现代应用药学,2018,35(12):1831-1836. |
| TIAN Wei,ZHEN Yaqin,GAO Le,FAN Shuaishuai,LI Junshan,NIU Liying.Research on Chrysanthemi Indici Flos Standard Decoction[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(12):1831-1836. |
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| 野菊花饮片标准汤剂的研究 |
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田伟1,2,3, 甄亚钦1,2,3, 高乐1,2,3, 范帅帅1, 李军山2,3,4, 牛丽颖1,2,3
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1.河北中医学院, 石家庄 050091;2.河北省中药配方颗粒工程技术研究中心, 石家庄 050091;3.河北省高校中药配方颗粒应用技术研发中心, 石家庄 050091;4.神威药业集团有限公司, 石家庄 051430
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| 摘要: |
| 目的 制备野菊花饮片标准汤剂，并进行质量研究。方法 依照标准汤剂的制备要求，制备15批不同产地的野菊花饮片标准汤剂，以蒙花苷作为定量检测指标，计算转移率与出膏率，并建立其UPLC特征图谱分析方法。结果 通过对15批野菊花标准汤剂进行测定，蒙花苷转移率为29.6%~38.2%，出膏率为23.1%~31.4%；并用中药色谱指纹图谱相似度评价系统软件进行特征图谱分析，标定了12个共有峰，指认了其中9个峰，对15批野菊花饮片标准汤剂分别进行了相似度评价，其相似度均>0.90。结论 野菊花饮片标准汤剂制备规范，测定方法精密度、稳定性和重复性良好，可为野菊花配方颗粒的质量控制提供参考。 |
| 关键词: 野菊花 标准汤剂 配方颗粒 转移率 特征图谱 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.12.016 |
| 分类号:R917.101 |
| 基金项目:河北省中医药管理局科研计划项目（2017015） |
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| Research on Chrysanthemi Indici Flos Standard Decoction |
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TIAN Wei1,2,3, ZHEN Yaqin1,2,3, GAO Le1,2,3, FAN Shuaishuai1, LI Junshan2,3,4, NIU Liying1,2,3
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1.Hebei University of Chinese Medicine, Shijiazhuang 050091, China;2.Hebei TCM Formula Granule Engineering & Technology Research Center, Shijiazhuang 050091, China;3.TCM Formula Granule Research Center of Hebei Province University, Shijiazhuang 050091, China;4.Shineway Pharmaceutical Group Ltd., Shijiazhuang 051430, China
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| Abstract: |
| OBJECTIVE To prepare Chrysanthemi Indici Flos standard decoction and to study the quality standard. METHODS Fifteen batches of Chrysanthemi Indici Flos standard decoction were prepared according to the standardization method. With buddleoside as the quantitative detection index, the transfer rate and extraction rate were calculated and the UPLC characteristic chromatogram analysis method was established. RESULTS According to the measurement of 15 batches of Chrysanthemi Indici Flos standard decoction, the transfer rate ranged from 29.6% to 38.2% and extraction rate was at the range of 23.1%~31.4%. The Similarity Evaluation Chromatographic Fingerprint of traditional Chinese medicine TCM was used to analyze and compare the characteristic chromatograms, 12 common peaks were determined and 9 of them were identified. Moreover, the similarities were all over 0.90. CONCLUSION Samples were prepared by a standard method. The determination method displayed good precision, stability and repeatability. Therefore, this study can provide a reference for the quality control of Chrysanthemi Indici Flos formula granules. |
| Key words: Chrysanthemi Indici Flos standard decoction formula granules transfer rate characteristic chromatogram |
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