| 引用本文: | 陈炜,陈婉姬,杨明华.胃复春片对功能性消化不良大鼠胃肠功能的影响[J].中国现代应用药学,2019,36(7):829-832. |
| CHEN WEI,CHEN Wanji,YANG Minghua.Effect of Wei Fuchun Tablet on Gastrointestinal Function in Functional Dyspesia Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(7):829-832. |
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| 摘要: |
| 目的 考察胃复春片对胃肠动力障碍的改善作用。方法 建立功能性消化不良（functional dyspepsia，FD）大鼠模型；以FD大鼠体质量、进食量、饮水量、胃平滑肌电活动情况、胃液分泌量、胃蛋白酶活性、肝脏与脾脏质量、胃病理情况等考察胃复春的药效。结果 模型组FD大鼠胃平滑肌电活动明显紊乱，体质量、进食量、饮水量明显减少、胃蛋白酶活性明显降低；经胃复春治疗后，上述现象明显缓解，大鼠体质量、进食量、饮水量明显增加，胃蛋白酶活性明显升高。结论 胃复春能改善FD大鼠的一般状况，对FD大鼠胃酸过多有抑制作用，能提高模型大鼠的胃蛋白酶活性。 |
| 关键词: 胃复春 功能性消化不良 胃肠功能 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.07.012 |
| 分类号:R284.1 |
| 基金项目: |
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| Effect of Wei Fuchun Tablet on Gastrointestinal Function in Functional Dyspesia Rats |
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CHEN WEI1, CHEN Wanji2, YANG Minghua3
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1.Hangzhou Huqingyutang Pharmaceutical Co., Ltd., Hangzhou 310015, China;2.Tongde Hospital of Zhejiang Province, Hangzhou 310012, China;3.Zhejiang Research Institute of Traditional Chinese Medicine Co., Ltd., Hangzhou 310023, China
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| Abstract: |
| OBJECTIVE To explore the improvement effect of Wei Fuchun tablet on gastrointestinal motility disorder. METHODS Functional dyspepsia(FD) rat model was established. Weight, diet, drinking, electrical activity of stomach muscle, gastric secretion, activity of gastric pepsin, the weight of liver and spleen, gastric pathology was used to observe the effect of Wei Fuchun tablet on FD rats. RESULTS The electrical activity of stomach muscle of FD rats in model group was obviously disordered, weight, diet, drinking and gastric pepsin activity were significantly decreased. After the treatment of Wei Fuchun tablet, the above phenomena were alleviated, weight, diet, drinking and gastric pepsin activity were significantly increased. CONCLUSION Wei Funchun tablet can improve the general state of the FD rats, inhibite gastric acid secretion and improve activity of gastric pepsin in model rats. |
| Key words: Wei Funchun tablet functional dyspepsia gastrointestinal function |
