糖肽类抗菌药物利用评价标准的建立与应用分析

Establishment and Application of Drug Use Evaluation Criteria for Glycopeptides Antibiotics

关键词:  糖肽类抗菌药物  万古霉素  替考拉宁  药物利用评价

Key words:  glycopeptides antibiotics  vancomycin  teicoplanin  drug use evaluation

摘要:

目的 建立糖苷类抗菌药物（万古霉素和替考拉宁）的药物利用评价标准，并评价糖肽类抗菌药物临床用药情况。方法 以药品说明书为基础，参照相关规范和专家共识，建立万古霉素和替考拉宁药物利用评价标准；采用回顾性研究方法，对2017年1月-6月274例使用万古霉素和替考拉宁的病例进行合理性评价。结果 糖肽类抗菌药物治疗有效率为75.91%，用药指征符合率为92.70%，剂量正确率为98.18%，用法正确率为91.24%，疗程合理率为79.93%，联合用药合理率为72.26%。结论 建立的万古霉素和替考拉宁药物利用评价标准可用于规范糖肽类抗菌药物的使用，该院万古霉素和替考拉宁的使用基本合理。

Abstract:

OBJECTIVE To establish drug use evaluation(DUE) criteria for vancomycin and teicoplanin, to evaluate clinical use of glycopeptides antibiotics in a hospital of the three levels of first class. METHODS Based on vancomycin and teicoplanin instructions, referring to related specifications and literatures, DUE criteria for vancomycin and teicoplanin were established. The utilization of glycopeptides antibiotics in 274 inpatients of the hospital during Jan 2017-Jun 2017 was evaluated in retrospective study. RESULTS The treatment effective rate of glycopeptides antibiotics was 75.91%, the coincidence rate of medication indication was 92.70%, the rate of accuracy dosage was 98.18%, the rate of accuracy administration was 91.24%, the rate of rational duration of treatment was 79.93%, the rate of rational combined drug was 72.26%. CONCLUSION Established DUE criteria of vancomycin and teicoplanin can standardize the clinical utilization of glycopeptides antibiotics, clinical use of vancomycin and teicoplanin is basically reasonable in this hospital.