补肾活血方联合盐酸多奈哌齐对血管性痴呆患者认知功能与血液流变学的影响

Study on the Effect of Bushen Huoxue Decoction Combined with Donepezil Hydrochloride on Cognitive Function and Hemorheology in Vascular Dementia

关键词:  血管性痴呆  补肾活血方  认知功能  炎症因子  血液流变学

Key words:  vascular dementia  Bushen Huoxue Decoction  cognitive function  inflammatory factors  hemorheology

摘要:

目的 研究补肾活血方联合盐酸多奈哌齐对血管性痴呆患者认知功能与血液流变学的影响。方法 选取92例血管性痴呆患者，按随机数表法分为研究组及对照组，各46例。对照组给予常规治疗并口服盐酸多奈哌齐，研究组在对照组基础上给予补肾活血方，比较治疗前后2组患者日常生活能力量表（activity of daily living，ADL）评分、长谷川痴呆量表（hasegawa dementia scale，HDS）评分、简易精神状态量表（minimum mental state examination，MMSE）评分、血液流变学指标水平（红细胞压积、血浆黏度、全血低切还原黏度与高切还原黏度）、炎症因子水平、中医症状评分及治疗有效率。结果 治疗后，研究组HDS、MMSE与ADL评分均明显优于对照组（P<0.01）；血液流变学指标、炎症因子水平较对照组显著改善（P<0.01）；中医症状改善明显优于对照组（P<0.05）；研究组治疗有效率高达93.48%，对照组为73.91%，差异有统计学意义（P<0.05）。结论 血管性痴呆患者给予补肾活血方联合盐酸多奈哌齐治疗更有利于提高HDS、MMSE与ADL评分，改善中医症状与认知能力，缓解炎症反应，降低血液流变学指标，治疗效果更为显著。

Abstract:

OBJECTIVE To study the effect of Bushenhuoxuefang combined with donepezil hydrochloride on cognitive function and hemorheology in patients with vascular dementia. METHODS Ninety two patients with vascular dementia were selected, which were randomly divided into study group and control group, 46 cases each group. The control group received routine treatment and oral treatment with donepezil hydrochloride. The study group was given Bushen Huoxue Decoction on the basis of the control group. Activities of daily living (ADL) score, hastgawa dementia scale (HDS) score, mini-mental state examination (MMSE) score, hemorheology index levels (hematocrit, plasma viscosity, whole blood low-cut reduction viscosity and high-cut reduction viscosity), the level of inflammatory factors, TCM symptoms scores and treatment efficiency were compared between the two groups before and after treatment. RESULTS After treatment, the HDS, MMSE and ADL scores of study group were significantly better than those of control group (P<0.01); hemorheology index and inflammatory factor levels were significantly more improved than those of control group (P<0.01); the TCM symptoms improved significantly better than those of control group (P<0.05); the efficiency of study group was as high as 93.48%, the control group was 73.91%, the difference was statistically significant(P<0.05). CONCLUSION Patients with vascular dementia who received Bushenhuoxuefang combined with donepezil hydrochloride was more conducive to improving the HDS, MMSE and ADL scores, improving the TCM symptoms and cognitive function, relieving the inflammatory reactions, reducing hemorheology indexes, and improving treatment effects.