| 引用本文: | 孙晶晶,席建军,潘旭旺,邵益丹,方红英,潘金明,张建康,庄让笑,游剑.新型抗肝损伤化合物XXH-32脂质体的制备及其药剂学性质研究[J].中国现代应用药学,2019,36(4):411-416. |
| SUN Jingjing,XI Jianjun,PAN Xuwang,SHAO Yidan,FANG Hongying,PAN Jinming,ZHANG Jiankang,ZHUANG Rangxiao,YOU Jian.Preparation and Characteristics Study of Novel Anti-liver Injury Compound XXH-32 Liposome[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(4):411-416. |
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| 新型抗肝损伤化合物XXH-32脂质体的制备及其药剂学性质研究 |
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孙晶晶1,2, 席建军2, 潘旭旺2, 邵益丹2, 方红英2, 潘金明2, 张建康2, 庄让笑2, 游剑1
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1.浙江大学药学院, 杭州 310058;2.杭州市西溪医院, 杭州 310023
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| 摘要: |
| 目的 制备新型抗肝损伤化合物XXH-32脂质体，并对其药剂学性质进行研究。方法 采用薄膜分散法制备脂质体，正交试验设计考察影响制备工艺的因素，用扫描电镜观察脂质体表面形态，对制备的XXH-32脂质体的粒径、载药量、包封率等性质及体外释放特性进行了研究。结果 XXH-32脂质体的最佳制备工艺稳定，脂质体形态圆整，粒径分布适宜。优化工艺制得的脂质体平均粒径为（175.2±2.55）nm，多分散系数为0.262±0.01，载药量为（2.60±0.12）%，包封率为（95.05±1.06）%，体外释放符合一级动力学方程，ln（100-Q）=-0.06t+4.79（R2=0.979 4）。结论 本实验获得了较理想的新型抗肝损伤化合物XXH-32脂质体，其体外释药特性符合缓释制剂特征。 |
| 关键词: 新型化合物 XXH-32脂质体 体外释放 缓释 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.04.006 |
| 分类号:R944.9 |
| 基金项目:杭州市科技发展计划项目（20142013A60） |
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| Preparation and Characteristics Study of Novel Anti-liver Injury Compound XXH-32 Liposome |
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SUN Jingjing1,2, XI Jianjun2, PAN Xuwang2, SHAO Yidan2, FANG Hongying2, PAN Jinming2, ZHANG Jiankang2, ZHUANG Rangxiao2, YOU Jian1
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1.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;2.Xixi Hospital of Hangzhou, Hangzhou 310023, China
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| Abstract: |
| OBJECTIVE To prepare a novel anti-liver injury compound XXH-32 liposome and study its pharmaceutical properties. METHODS The liposome was prepared by thin-film dispersion method. The optimized preparation process was investigated by a series of experiments under orthogonal design. The surface morphology of the liposome was observed by scanning electron microscopy. The particle size and drug loading of the liposome was measured, and XXH-32 release behavior from the liposome was studied. RESULTS Under the optimal preparation process, the liposome was presented round in shape with average diameter of (175.2±2.55)nm, polymer dispersity index was 0.262±0.01. The content of XXH-32 in the liposome was (2.60±0.12)%, and the entrapment efficiency was (95.05±1.06)%. The release of XXH-32 from the liposome presented a first-order kinetic behavior. The equation as follow ln(100-Q)=-0.06t+4.79, R2=0.979 4. CONCLUSION XXH-32 liposome was prepared successfully with high drug entrapment efficiency. XXH-32 in the liposome showed a significantly slower release behavior. |
| Key words: novel compound XXH-32 liposome drug release in vitro sustained-release |
