弹性脂质囊泡在经皮给药系统的研究进展

Advances in Research of Elastin Lipid Vesicles in Transdermal Delivery System

关键词:  弹性脂质囊泡  醇质体  传递体  类脂囊泡  经皮给药

Key words:  elastic lipid vesicles  alcoholic bodies  transfersomes  lipid vesicles  transdermal delivery

摘要:

目的 对近年来弹性脂质囊泡在经皮给药系统的研究与应用进行文献整理和归纳，为以后该领域的研究提供借鉴。方法 查阅近5年弹性脂质囊泡在经皮给药系统的相关文献，总结弹性脂质囊泡的分类、制备方法、促透机制、应用的研究进展，提出其今后研究的重点方向。结果 弹性脂质囊泡具有较好的变形性、皮肤渗透性，可以通过角质层，更利于药物到达毛细血管被吸收，提高生物利用度，更有利于皮肤用药。结论 弹性脂质囊泡经皮给药系统是一种安全、有效的给药途径，其顺应性更好，在经皮给药方面有很好的应用前景。

Abstract:

OBJECTIVE To summarize the research and application of elastic lipid vesicles in transdermal delivery systems in recent years, and to provide reference for future research in this field. METHODS The literature on the classification and preparation of elastin lipid vesicles, the mechanism of penetration promotion, and the application of the lipid-containing lipid vesicles were reviewed by referring to the related literature on transdermal delivery of elastic lipid vesicles for the past 5 years direction. RESULTS Elastin lipid vesicles had good deformability and skin permeability, and could pass through the stratum corneum, which was more conducive to drug absorption into the blood, improved bioavailability, and was more conducive to skin drug use. CONCLUSION The transdermal delivery system of elastin lipid vesicles is a safe and effective route of administration, with better compliance and promising application in transdermal delivery.