羟基红花黄色素A改善缺血性脑卒中机制的研究进展

Mechanism of Hydroxysafflor Yellow A Meliorating Ischemia Stroke:A Literature Review

关键词:  羟基红花黄色素A  脑缺血  炎症  氧化应激

Key words:  hydroxysafflor yellow A  brain ischemia  inflammation  oxidative stress

摘要:

脑卒中作为全球范围内主要致死因素之一，对社会造成了很大的负担。羟基红花黄色素A作为红花主要的有效水溶性成分，具有抗炎、抗氧化、抗凋亡、改善微循环、矫正受损代谢通路、调控血管平滑肌细胞增殖和迁移等药理作用，能够有效治疗缺血性脑卒中。目前，利用大脑中动脉栓塞等模型探究羟基红花黄色素A对于缺血性脑卒中治疗及预后的相关研究日益增多。本文根据相关文献资料进行分析、整理和归纳，综述了羟基红花黄色素A改善缺血性脑卒中的药理机制以及相关治疗和预后。

Abstract:

As one of the leading causes of mortality worldwide, stroke brings a great burden to the society. Hydroxysafflor yellow A is a major active water-soluble component of the flower of Carthamus tinctorius, which is an effective agent against ischemia stroke. Hydroxysafflor yellow A has wide-reaching biological activities, including anti-inflammation, antioxidation, anti-apoptosis, improving microcirculation, corrections of the impaired metabolic pathways, modulating the proliferation and migration of vascular smooth muscle cells and so on. Currently, there is an increasing number of related research devoted in investigating the effect of hydroxysafflor yellow A on treatment and prognosis of ischemia stroke through models including middle cerebral artery occlusion. This article aims at analyzing and concluding the information from relevant literatures, summing up the pharmacological mechanisms, treatment and prognosis of hydroxysafflor yellow A in ischemia stroke.