| 引用本文: | 陈光宇,宋毓涛,刘又嘉,瞿昊宇,何群,谢梦洲.响应面设计试验法优化沙棘固本速溶茶低温喷雾干燥工艺[J].中国现代应用药学,2019,36(12):1516-1521. |
| CHEN Guangyu,SONG Yutao,LIU Youjia,QU Haoyu,HE Qun,XIE Mengzhou.Optimization of Low-temperature Spray-Drying Process of Sea-buckthorn Strengthening Tea Granules by Response Surface Methodology[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(12):1516-1521. |
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| 响应面设计试验法优化沙棘固本速溶茶低温喷雾干燥工艺 |
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陈光宇1,2, 宋毓涛1, 刘又嘉1, 瞿昊宇1,2, 何群1, 谢梦洲1,2
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1.湖南省药食同源功能性食品工程技术研究中心, 长沙, 410208;2.湖南中医药大学中医诊断研究所, 长沙 410208
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| 摘要: |
| 目的 优化沙棘固本速溶茶最佳低温喷雾干燥工艺参数，为工业化生产提供依据。方法 采用苯酚-硫酸比色法测定沙棘固本速溶茶干浸膏粉中多糖含量，HPLC测定沙棘固本速溶茶干浸膏粉中人参皂苷Re、Rg1、Rb1的含量，以干浸膏粉质量、多糖含量及人参皂苷Re、Rg1、Rb1含量为评价指标，单因素试验法及响应面设计试验法优化沙棘固本速溶茶低温喷雾干燥工艺参数。结果 最优低温喷雾干燥工艺参数如下：药液相对密度1.08 g·mL-1，进风温度120℃，泵药速度20 RPM，风机速度25 m3·h-1，雾化压强0.4 Mpa。结论 沙棘固本速溶茶提取浓缩液适合采用低温喷雾干燥法制备干浸膏粉，低温喷雾干燥系瞬间干燥，速度快，对功能性成分影响小；优选的最佳低温喷雾干燥工艺参数科学、合理、可行、成熟稳定，适合工业化生产。 |
| 关键词: 沙棘固本速溶茶 多糖 人参皂苷 低温喷雾干燥 干浸膏粉 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.12.013 |
| 分类号:R284.2 |
| 基金项目:湖南省科技计划项目（2016SK2034） |
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| Optimization of Low-temperature Spray-Drying Process of Sea-buckthorn Strengthening Tea Granules by Response Surface Methodology |
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CHEN Guangyu1,2, SONG Yutao1, LIU Youjia1, QU Haoyu1,2, HE Qun1, XIE Mengzhou1,2
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1.Engineering Center of Medicinal and Edible Functional Food, Hunan University of Chinese Medicine, ChangSha 410208, China;2.Institute of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha 410208, China
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| Abstract: |
| OBJECTIVE To optimize parameters of low-temperature spray-drying process of Sea-buckthorn Strengthening Tea granules, provide the basis for industrialization. METHODS The polysaccharide content in Sea-buckthorn Strengthening Tea granules was measured by phenol-dense sulphuric acid method. The content of ginsenoside Re, Rg1, Rb1 in Sea-buckthorn Strengthening Tea granules were measured by HPLC. The amount percent of weight, polysaccharide content and the content of ginsenoside Re, Rg1, Rb1 of dry granulation were taken as the indexes of low-temperature spray-drying process evaluation. Then the low-temperature spray-drying process parameters of Sea-buckthorn Strengthening Tea granules were optimized by single factor experiment and response surface methodol. RESULTS These low-temperature spray-drying process parameters after optimized were as follows:relative density was 1.08 g·mL-1 in spray-drying, inlet air temperature was 120℃, speed of peristaltic pump was 20 RPM, fan speed was 25 m3·h-1, compression pressure was 0.4 Mpa. CONCLUSION Low-temperature spray-drying process is suit for extraction concentrate solution from Sea-buckthorn Strengthening Tea to prepare dry granules. Low-temperature spray-drying have smaller impact on functional ingredient with faster speed. These best low-temperature spray-drying process parameters after optimized of Sea-buckthorn Strengthening Tea are scientific, reasonable, feasible, mature, stable. This optimized low-temperature spray-drying process is suitable for its industrialized production |
| Key words: Sea-buckthorn Strengthening Tea granules polysaccharide ginsenoside low-temperature spray-drying dry granulation |
