基于肾功能情况的左氧氟沙星合理用药分析

Evaluate the Retionality of Levofloxacin Based on Renal Function

关键词:  左氧氟沙星  老年人  肾功能  肾小球滤过率  剂量调整

Key words:  levofloxacin  elder  renal function  GFR  dose adjustment

摘要:

目的 结合肾功能情况分析住院患者左氧氟沙星的用药合理性。方法 检索2016年7月1日-2017年6月30日住院部使用左氧氟沙星的病例，等距抽样法随机抽查200例进行详细分析。结果 男女各100例，年龄（69.1±17.3）岁，不合理用药43例，发生不良反应22例，多发于老年人和慢性肾功能不全患者。估算肾小球滤过率<50 mL·min^-1·（1.73 m²）^-1的患者31例，平均年龄（80.3±16.1）岁。超剂量给药30例，其中8例血肌酐仍在正常范围内。结论 左氧氟沙星仍未能很好地按照肾功能情况调整剂量，特别是高龄人群。临床药师可借助计算机系统开展多学科合作模式，提高左氧氟沙星的用药合理性。

Abstract:

OBJECTIVE To analyze the rationality of levofloxacin in the inpatient department according to the renal function. METHODS Two hundred cases of patients treated with evofloxacin in the inpatient department from 2016.7.1-2017.6.30 were checked for detailed analysis in random using interval sampling method. RESULTS There were 100 cases of male and 100 cases of female patients, with the age of (69.1±17.3) years, 43 cases of irrational drug use, 22 cases of adverse reactions, elderly patients and patients with chronic renal insufficiency were more common. There were 31 patients whose estimated glomerular filtration rate <50 mL·min^-1·(1.73 m²)^-1, with an average age of (80.3±16.1)years, 30 cases was overdose and 8 cases' serum creatinine remained within the normal range. CONCLUSION In 2017, the dose of levofloxacin was not adjusted well according to the renal function, especially in the elder patients. Clinical pharmacists shall develop multidisciplinary cooperation models with the aid of computer to improve the rational use of levofloxacin.