| 引用本文: | 王秀秀,邹丽,钱薇,许正新.黄酮类化合物对心肌细胞离子通道作用的研究进展[J].中国现代应用药学,2019,36(7):885-887. |
| WANG Xiuxiu,ZOU Li,QIAN Wei,XU Zhengxin.Research Progress of Effects of Flavonoids on Ion Channels of Cardiomyocytes[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(7):885-887. |
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| 黄酮类化合物对心肌细胞离子通道作用的研究进展 |
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王秀秀1, 邹丽1, 钱薇1, 许正新1,2,3,4
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1.扬州大学医学院药理教研室, 江苏 扬州 225000;2.江苏省重点动物传染病和人畜共患病预防控制共创中心, 江苏 扬州 225001;3.江苏省中西医结合老年病防治重点实验室, 江苏 扬州 225001;4.江苏省非编码 RNA 基础与临床转化重点实验室, 江苏 扬州 225009
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| 摘要: |
| 目的 深入了解黄酮类化合物抗心律失常方面的作用特点及机制。方法 通过文献调研，从离子通道角度对黄酮类化合物抗心律失常方面的研究进展进行深入归纳和总结。结果 不同类别的黄酮类化合物对钠、钾、钙通道的某些类型具有不同的影响，这些特点构成了其抗心律失常作用的物质基础。结论 黄酮类化合物对心律失常具有良好的防治作用，对此类化合物的深入开发与利用具有重要的临床意义和应用前景。 |
| 关键词: 黄酮类化合物 膜片钳技术 心肌细胞 离子通道 心律失常 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.07.023 |
| 分类号:R285 |
| 基金项目: |
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| Research Progress of Effects of Flavonoids on Ion Channels of Cardiomyocytes |
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WANG Xiuxiu1, ZOU Li1, QIAN Wei1, XU Zhengxin1,2,3,4
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1.Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou 225000, China;2.Jiangsu Key Laboratory of Animal Infectious Diseases and Zoonosis Prevention and Control, Yangzhou 225001, China;3.Key Laboratory of Integrative Medicine Prevention and Treatment in Jiangsu Province, Yangzhou 225001, China;4.Jiangsu Key Laboratory of Non-coding RNA Basic and Clinical Transformation, Yangzhou 225009, China
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| Abstract: |
| OBJECTIVE To understand the characteristics and mechanism of flavonoids on anti-arrhythmia in depth. METHODS Through the method of literature research, the research progress of flavonoids on anti-arrhythmia from the perspective of ion channels were summarized. RESULTS Different flavonoids had different effects on some types of sodium, potassium and calcium channels, which constitute the material basis of their anti-arrhythmia effect. CONCLUSION Flavonoids have good preventive effects on arrhythmia, and have important clinical significance and application prospects for the in-depth development and utilization. |
| Key words: flavonoids whole-cell patch clamp technique cardiomyocytes ion channels arrhythmia |
