| 引用本文: | 肖蔚林,王均华,陈文亮,毛一凡,张佳锋,刘钟,杨依然,史晓林.强骨饮对骨质疏松症患者预防跌倒作用的临床研究[J].中国现代应用药学,2019,36(14):1797-1801. |
| XIAO Weilin,WANG Junhua,CHEN Wenliang,MAO Yifan,ZHANG Jiafeng,LIU Zhong,YANG Yiran,SHI Xiaolin.Clinical Study on Qiangguyin in Preventing Fall with Osteoporosis[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(14):1797-1801. |
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| 摘要: |
| 目的 观察口服自拟中药益气温经方强骨饮对骨质疏松症患者预防跌倒作用的临床疗效。方法 将入选的186例原发性骨质疏松症患者随机分成2组：治疗组（强骨饮+阿法迪三+钙尔奇），对照组（阿法迪三+钙尔奇），各93例，均维持治疗6个月，对比2组患者治疗前后的定量CT（quantitative computed tomography，QCT）腰椎骨密度、骨转换指标和腰背疼痛、腰膝酸软、下肢痿弱及步履艰难等中医症状评分情况。结果 2组各有90例患者完成本次试验。治疗组在改善骨质疏松症患者腰背疼痛、腰膝酸软、下肢痿弱及步履艰难等中医症状方面疗效显著，治疗前后比较以及与对照组相比较，差异均有统计学意义（P<0.05）；在改善QCT腰椎骨密度及骨转换指标方面亦有良好效果，治疗前后差异有统计学意义（P<0.05）；与对照组相比较，QCT腰椎骨密度、血清Ⅰ型前胶原氨基端前肽差异无统计学意义，血清Ⅰ型胶原交联C末端肽差异有统计学意义（P<0.05）。结论 强骨饮联合维生素D与钙剂对骨质疏松症患者预防跌倒作用显著，值得临床推广和深入研究。 |
| 关键词: 骨质疏松症 骨折 跌倒 预防跌倒 骨痿 强骨饮 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.14.014 |
| 分类号:R969.4 |
| 基金项目:2018年度浙江省中医药重点研究项目（2018ZZ012） |
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| Clinical Study on Qiangguyin in Preventing Fall with Osteoporosis |
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XIAO Weilin1, WANG Junhua1, CHEN Wenliang1, MAO Yifan1, ZHANG Jiafeng1, LIU Zhong1, YANG Yiran1, SHI Xiaolin2
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1.Second Clinical Medical College, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China;2.The Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310005, China
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| Abstract: |
| OBJECTIVE To observe the clinical efficacy of oral Chinese herbal medicine Yiqiwenjingfang Qiangguyin in preventing falls in patients with osteoporosis. METHODS A total of 186 patients with primary osteoporosis were randomly divided into 2 groups:the treatment group(Qianguyin+Afadi Ⅲ+Calcium), and the control group(Afadi Ⅲ+ Calcium), each in 93 cases, the 2 groups of patients were treated for 6 months. The scores of quantitative computed tomography(QCT) lumbar spine bone mineral, bone turnover index and low back pain, weak waist and knees, weak lower limbs and difficult walking were compared between the 2 groups. RESULTS Ninety patients in each group completed the trial. The treatment group was effective in improving the symptoms of low back pain, weak waist and knees, weak limbs and difficulty in walking. Compared with the control group, the difference was statistically significant(P<0.05). It also had good effect in improving the bone mineral density and bone turnover index of QCT. The difference before and after treatment was statistically significant(P<0.05). Compared with the control group, there was no significant difference in QCT lumbar spine bone mineral density and N-terminal propeptide of typeⅠprecollagen, and the difference of C-terminal telopeptides of serum typeⅠcollagen was statistically significant(P<0.05). CONCLUSION Qianguyin combined with vitamin D and calcium has a significant effect on preventing falls in patients with osteoporosis, which is worthy of clinical promotion and in-depth study. |
| Key words: osteoporosis fracture fall prevention of fall osteophytes Qianguyin |
