护肝片对药物性肝损伤的防治作用

Prevention and therapeutic effects to Drug-induced Liver Injury with Liver-aid Tablets

关键词:  护肝片  药物性肝损伤  阿托伐他汀钙片  保护  治疗

Key words:  liver-aid tablets  drug-induced liver injury  atorvastatin  protection  treatment

摘要:

目的 研究护肝片对药物性肝损伤的预防和治疗作用。方法 采用阿托伐他汀钙片灌胃♂SD大鼠建立药物性肝损伤动物模型，通过检测大鼠血清中丙氨酸转氨酶（alanine aminotransferase，ALT）、天门冬氨酸氨基转移酶（aspartate aminotransferase，AST）、碱性磷酸酶（alkaline phosphatase，ALP）、总胆红素（total bilirubin，TBIL）、直接胆红素（direct bilirubin，DBIL）、白蛋白（albumin，ALB）、总蛋白（total protein，TP）水平及观察肝组织病理切片，探讨护肝片对药物性肝损伤防治效果。结果 护肝片能显著降低阿托伐他汀诱导的大鼠血清中ALT、AST、ALP和TBIL水平（P<0.01，P<0.05）。结论 护肝片对阿托伐他汀致药物性肝损伤具有一定的保护和治疗作用。

Abstract:

OBJECTIVE To evaluate the protective and therapeutic effect of liver-aid tablets on atorvastatin-induced hepatic injury. METHODS The model of drug-induced liver injury in ♂ SD rats was established by intragastric administration of atorvastatin. The serum levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase (ALP), total bilirubin(TBIL), direct bilirubin(DBIL), albumin(ALB), total protein(TP) and liver histopathology were detected to investigate the effect of liver-aid tablets on protecting and treating liver in atorvastatin-induced hepatic injury. RESULTS Liver-aid tablets could significantly reduce the levels of ALT, AST, ALP and TBIL(P<0.01, P<0.05) in the model group. CONCLUSION Liver-aid tablets have a hepatoprotective effect against atorvastatin-induced hepatic injury to some extent.