| 引用本文: | 李晓黎,尹影,李蕊,吴坤荣,关紫菀,李妍.转运体介导的二甲双胍药物相互作用研究进展[J].中国现代应用药学,2019,36(13):1711-1715. |
| LI Xiaoli,YIN Ying,LI Rui,WU Kunrong,Guan Ziwan,LI Yan.Advances in transporter-mediated drug interactions with metformin[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(13):1711-1715. |
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| 转运体介导的二甲双胍药物相互作用研究进展 |
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李晓黎,尹影,李蕊,吴坤荣,关紫菀,李妍
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1.山东第一医科大学/山东省医学科学院 药学院, 山东 泰安 271000;2.山东大学药学院, 山东 济南 250014;3.山东省千佛山医院药学部, 山东 济南 250014
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| 摘要: |
| 二甲双胍作为治疗2型糖尿病的一线药物广泛应用于临床。多种转运体参与二甲双胍的体内处置过程，对药物的吸收、分布及排泄行为有重要影响。某些药物可影响转运体的功能，当其与二甲双胍联用时，有可能引起后者药动学和药效学的改变，从而导致不良的临床治疗结局。本文通过查阅和分析相关文献，将转运体介导的与二甲双胍相关的药物相互作用作一综述，旨在为二甲双胍的合理应用提供依据。 |
| 关键词: 二甲双胍 2型糖尿病 药物相互作用 转运体 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.13.023 |
| 分类号:R285.5 |
| 基金项目:山东省自然科学基金项目（ZR2010HL017）；济南市科技计划项目（201602171） |
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| Advances in transporter-mediated drug interactions with metformin |
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LI Xiaoli1,2, YIN Ying1,2, LI Rui3, WU Kunrong3, Guan Ziwan3, LI Yan1,2,4
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1.Department of Pharmacy, Shandong First Medical University & amp;2.Shandong Academy of Medical Sciences, Tai'an 271000, China;3.School of Pharmaceutical Sciences, Shandong University, Jinan 250014, China;4.Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Jinan 250014, China
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| Abstract: |
| As the first-line treatment for type 2 diabetes, metformin is widely used in clinical practice. Various transporters are associated with the absorption, distribution and excretion of metformin in vivo. Drugs concerning with these transporters may change pharmacokinetics and pharmacodynamics of metformin, leading to adverse drug interactions. The transporter-mediated drug-drug interactions were reviewed to provide a basis for rational application of metformin. |
| Key words: metformin type 2 diabetes drug interaction transporters |
