| 引用本文: | 黄远,李菁,徐科一,王德勤,杨子峰.板蓝根抗流感病毒有效成分研究进展[J].中国现代应用药学,2019,36(20):2618-2623. |
| HUANG Yuan,LI Jing,XU Keyi,WANG Deqin,YANG Zifeng.Research Progress on Anti-influenza Effective Components of Isatidis Radix[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(20):2618-2623. |
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| 摘要: |
| 板蓝根为十字花科植物菘蓝的干燥根，是清热解毒、凉血利咽的代表性中药，临床上常用于防治呼吸道病毒性疾病。目前，板蓝根中的逾百种化学成分被鉴定，分子多样性十分丰富，然而对于这些化合物如抗流感病毒有效成分的药理活性等多缺乏系统评价和论述。本文综述了板蓝根活性成分分离和鉴定的最新概况，深入探讨板蓝根抗流感病毒抗炎药效活性成分的现代药理研究新进展，为中药材二次开发研究及其应用提供新的思路和参考。 |
| 关键词: 板蓝根 清热解毒 抗病毒 抗炎 流感 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.20.027 |
| 分类号:R285 |
| 基金项目:中国博士后科学基金项目（2017M622652）；广东省名优中成药二次开发项目（20174005）；广州市博士后国际培养计划资助项目（2017121431） |
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| Research Progress on Anti-influenza Effective Components of Isatidis Radix |
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HUANG Yuan1,2, LI Jing1, XU Keyi2, WANG Deqin2, YANG Zifeng1
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1.State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510120, China;2.Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co., Ltd., Guangzhou 510515, China
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| Abstract: |
| Isatidis Radix is the dry root of Isatis indigotica Fort. of the Brassicaceae plant. It is a representative traditional Chinese medicine for clearing away heat and detoxifying, cooling blood and relieving pharynx. It is commonly used in the prevention and treatment of respiratory viral diseases. At present, more than one hundred chemical components in Isatidis Radix have been identified, and the molecular diversity is very rich. However, there is a lack of systematic evaluation and discussion on the pharmacological activities of these compounds, such as anti-influenza active ingredients. This article discusses the isolation and identification of Isatidis Radix active ingredients, then studies the modern pharmacological research progress of Isatidis Radix antiviral active ingredients against influenza. This review provides new ideas and references for secondary development and application of Chinese medicinal herbs. |
| Key words: Isatidis Radix clearing heat and detoxifying antiviral anti-inflammatory influenza |
