加味六味汤用于声带息肉术后康复治疗的临床观察

Observation on the Clinical Efficacy of Jiawei Liuwei Decoction for Post-operative Rehabilitation Treatment of Acousticular Pie

关键词:  加味六味汤  声带息肉  术后  辅助治疗  临床疗效

Key words:  Jiawei Liuwei decoction  sound polyps  post-operative  adjuvant treatment  clinical efficacy

摘要:

目的 观察加味六味汤用于声带息肉术后康复治疗的临床疗效。方法 以2016年1月-2017年7月首都医科大学附属北京安贞医院收治的130例声带息肉患者为研究对象，按随机数字表方式分为对照组（n=65）和研究组（n=65）。对照组患者给予支撑喉镜手术治疗，研究组患者在手术基础上，增加加味六味汤辅助治疗。观察患者治疗期间药物不良反应情况，比较患者术后3个月声带息肉临床症状评分，评价声带息肉疗效水平，随访患者术后1年内声带息肉复发情况。结果 术后3个月，研究组患者声音嘶哑、咽喉疼痛、咳嗽咯痰、喉咙异物感、声带充血、声门闭合和声带边缘肿胀等临床症状评分均显著低于对照组水平（P<0.05）；研究组患者治疗总有效率为93.85%，对照组为81.54%（χ²=4.561，P<0.05）；治疗期间，研究组患者药物不良反应总体发生率为（4.61%），术后随访1年，研究组声带息肉复发率（1.52%）显著低于对照组水平（10.77%）（χ²=4.795，P<0.05）。结论 较单纯手术治疗，术后辅助加味六味汤治疗可显著缓解声带息肉相关临床症状，提高声带息肉的总体疗效水平，预防声带息肉复发，且药物不良反应少，安全性较高，值得临床推广使用。

Abstract:

OBJECTIVE To observe the clinical efficacy of Jiawei Liuwei decoction for post-operative rehabilitation treatment of acousticular pie. METHODS One hundred and thirty cases of vocal polyp patients whom were admitted in the Beijing Anzhen Hospital, Capital Medical University from January 2016 to July 2017 were as research subjects, all the patients were divided into the control group(n=65) and the research group(n=65) by random digital form. The patients of the control group were treated with supportive laryngoscope. The patients of the study group were added Jiawei Liuwei decoction treatment on the basis of surgery. The adverse drug reactions during the treatment were observed, and the clinical symptoms scores of vocal cord polyps at 3 months after surgery were compared. The therapeutic effect of vocal cord polyps was evaluated. The recurrence of vocal cord polyps was followed up within one year. RESULTS Three months after surgery, the symptoms of patients in the study group such as hoarseness, sore throat, cough phlegm, throat foreign body sensation, vocal cord congestion, dry throat and vocal cord closure of the glottis, edge swelling and other clinical symptoms scores were significantly lower than the control group(P<0.05). The total effective rate of treatment in the study group was 93.85%, and that in the control group was 81.54% (χ²=4.561, P<0.05). During the treatment period, the overall incidence of adverse drug reactions was 4.61%. The recurrence rate of vocal cord polyps in the study group(1.52%) was significantly lower than that in the control group(10.77%)(χ²=4.795, P<0.05). CONCLUSION Compared with surgery alone, postoperative adjuvant Jiawei Liuwei decoction can significantly relieve the related clinical symptoms of vocal cord polyps, improve the overall efficacy of vocal cord polyps, prevent the recurrence of vocal cord polyps, and it have less adverse drug reactions, higher safety, which is worthy of clinical promotion and use.