抗肿瘤药物的耐药性及临床治疗对策

Drug Resistance of Antineoplastic Drugs and Clinical Therapeutic Strategies

关键词:  抗肿瘤药物  耐药性  机制  中药逆转剂  临床治疗对策

Key words:  antineoplastic drugs  drug resistance  mechanisms  traditional Chinese medicine reversal agents  clinical treatment strategies

摘要:

目的 总结抗肿瘤药物产生耐药性的相关机制，探讨临床治疗对策。方法 检索PubMed、Medline、Cochrane图书馆、中国期刊全文数据库（清华同方CJFD）、维普中文科技期刊全文数据库（VIP）、万方数据库发表与抗肿瘤药物的耐药性及临床治疗对策相关的文献，并结合当前抗肿瘤药物使用情况对其进行综述。结果 抗肿瘤药耐药性的产生受多种因素的影响，如药物外排增加使肿瘤细胞中的药物浓度降低、解毒作用加强、DNA修复损伤功能增加、肿瘤细胞通道信号异常、靶点改变等。结论 临床可根据产生耐药性的不同机制予以针对性治疗，中药具有多靶点作用，其逆转耐药优势突出。

Abstract:

OBJECTIVE To summarize the mechanism of antineoplastic drug resistance and explore the clinical treatment strategies. METHODS Retrieval of relevant literatures published in PubMed, Medline, Cochrane Library, CJFD, VIP and Wanfang databases on drug resistance and clinical treatment strategies of antineoplastic drugs was conducted, and the current use of antineoplastic drugs was reviewed. RESULTS The generation of antineoplastic drug resistance was influenced by many factors, such as the increase of drug efflux, the decrease of drug concentration in tumor cells, the enhancement of detoxification, the increase of DNA repair and damage function, the abnormal signal of tumor cell channels, and the change of target, et al. CONCLUSION Clinical treatment can be targeted according to the different mechanisms of drug resistance. Traditional Chinese medicine has multi-target effect, and its reversal of drug resistance has prominent advantages.