| 引用本文: | 王晓蕴,赵红敏,张忠勇,李华君,金倩倩,郭煊,孔五宝,牛跃龙.君子消痞汤加减对糖尿病胃轻瘫患者的疗效[J].中国现代应用药学,2019,36(20):2570-2575. |
| WANG Xiaoyun,ZHAO Hongmin,ZHANG Zhongyong,LI Huajun,JIN Qianqian,GUO Xuan,KONG Wubao,NIU Yuelong.Efficacy of Modified Prescription of Junzi Xiaopi Decoction on Diabetic Gastroparesis Patients[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(20):2570-2575. |
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| 君子消痞汤加减对糖尿病胃轻瘫患者的疗效 |
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王晓蕴,赵红敏,张忠勇,李华君,金倩倩,郭煊,孔五宝,牛跃龙
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河北省沧州中西医结合医院内分泌科, 河北 沧州 061001
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| 摘要: |
| 目的 探究君子消痞汤加减对糖尿病胃轻瘫患者的治疗效果。方法 选取2017年2月-2019年2月接受治疗的糖尿病胃轻瘫患者200例，随机分为常规治疗组以及观察治疗组，各100例。常规治疗组在基础治疗的基础上服用枸橼酸莫沙必利片，观察治疗组在常规治疗组的基础上服用君子消痞汤加减。检测胃动素、胃泌素、空腹血糖（fasting plasma glucose，FPG）、同型半胱氨酸（homocysteine，Hcy）及血清铁蛋白（serum ferritin，SF）水平；采用X射线钡餐检测胃排空时间；并统计患者治疗前后的症状积分、治疗后的总有效率以及不良反应发生率。结果 治疗后，与常规治疗组比较，观察治疗组患者胃动素、胃泌素、FPG、Hcy、SF表达水平，症状积分和不良反应发生率均明显降低（P<0.05），胃排空时间显著缩短，总有效率明显提高（P<0.05）。结论 君子消痞汤加减可以有效改善糖尿病胃轻瘫患者的临床症状，提高治疗总有效率，降低不良反应发生率。 |
| 关键词: 君子消痞汤 糖尿病 胃轻瘫 胃动素 胃泌素 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.20.017 |
| 分类号:R969.4 |
| 基金项目:河北省中医药管理局科研计划项目（2016137） |
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| Efficacy of Modified Prescription of Junzi Xiaopi Decoction on Diabetic Gastroparesis Patients |
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WANG Xiaoyun1,2, ZHAO Hongmin1,2, ZHANG Zhongyong1,2, LI Huajun1,2, JIN Qianqian1,2, GUO Xuan1,2, KONG Wubao1,2, NIU Yuelong1,2
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1.Department of Endocrinology, Cangzhou Hospital of Integrated TCM-WM·2.Hebei, Cangzhou 061001, China
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| Abstract: |
| OBJECTIVE To explore the therapeutic effect of Junzi Xiaopi decoction add and subtract on patients with diabetic gastroparesis. METHODS The 200 patients with diabetic gastroparesis from February 2017 to February 2019 were selected and randomly divided into routine treatment group and observation treatment group, 100 cases in each group. The routine treatment group was treated with mosapride citrate tablets on the basis of basic treatment. The treatment group was treated with Junzi Xiaopi decoction on the basis of routine treatment group. The levels of motilin, gastrin, fasting plasma glucose (FPG), homocysteine (Hcy) and serum ferritin (SF) were measured. X-ray barium meal was used to detect gastric emptying time. The total effective rate after treatment and the incidence of adverse reactions were also calculated. RESULTS After treatment, compared with routine treatment group, the expression levels of motilin, gastrin, FPG, Hcy, SF, the symptom score and the incidence of adverse reactions in observation treatment group were significantly lower(P<0.05). The gastric emptying time in the observation treatment group was significantly shorter than that in the routine treatment group(P<0.05). The total effective rate of the observation treatment group after treatment was significantly higher than that of the routine treatment group(P<0.05). CONCLUSION Junzi Xiaopi decoction can effectively improve the clinical symptoms of diabetic gastroparesis patients, improve the total effective rate, and reduce the incidence of adverse reactions. |
| Key words: Junzi Xiaopi decoction diabetic gastroparesis motilin gastrin |
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