泄浊解毒方结肠透析治疗慢性肾脏病4期患者短期疗效观察

Short-term curative effect of Xiezhuo Jiedu decoction Colon Dialysis in Patients of Chronic kidney disease Stage 4

关键词:  泄浊解毒方  结肠透析  慢性肾脏病4期  中医疗法

Key words:  xiezhuo jiedu decoction  colon dialysis  chronic kidney disease stage 4  therapeutic method of TCM

摘要:

目的 观察泄浊解毒方结肠透析治疗对慢性肾脏病（chronic kidney disease，CKD）4期患者的短期疗效。方法 纳入2017年1月-2018年1月CKD 4期住院患者，应用泄浊解毒方结肠透析治疗的65例患者为治疗组，未应用的60例为对照组。观察2组临床症状及血生化指标的变化。结果 与对照组比较，治疗组食欲不振、体倦乏力、便秘、皮肤瘙痒症状显著改善（P<0.05或P<0.01）。与治疗前及对照组比较，治疗组血肌酐、尿酸氮、血磷（P^3-）均显著下降（P<0.05）。治疗组总有效率（67.7%）显著高于对照组（48.3%）（P<0.05）。结论 泄浊解毒方结肠透析可有效改善CKD 4期患者临床症状及生化指标，短期疗效显著。

Abstract:

OBJECTIVE To retrospectively research the influence and short-term curative effect of Xiezhuo Jiedu decoction colon dialysis in patients with chronic kidney disease(CKD) stage 4. METHODS The patients of CKD stage 4 were collected in the clinical research from Jan 2017 to Jan 2018. The 65 patients treated with conventional therapy and colon herbs dialysis were selected as tested group, 60 patients with conventional therapy were selected as control group. The improvement in the clinical symptoms and blood biochemical indexes of the two groups were observed. RESULTS Compared with control group, the appetite,weakness of the body, constipation and skin itching symptoms of tested group improved significantly(P<0.05 or P<0.01). Compared with before treatment and control group, Scr, BUN and serum phosphorus of tested group were obviously lower(P<0.05). The total effective rate of tested group(67.7%) was significantly higher than that of control group(48.3%) (P<0.05). CONCLUSION Xiezhuo Jiedu decoction colon dialysis can effectively improve the clinical symptoms and biochemical indexes of the CKD stage 4 patients, the short-term effect is significant.