| 引用本文: | 陈奋,杨月,张玲,贾连群,潘卫三.姜黄素纳米制剂在肿瘤治疗中的研究进展[J].中国现代应用药学,2019,36(21):2731-2737. |
| CHEN Fen,YANG Yue,ZHANG Ling,JIA Lianqun,PAN Weisan.Research Progress of Curcumin Nano-preparations in Tumor Therapy[J].Chin J Mod Appl Pharm(中国现代应用药学),2019,36(21):2731-2737. |
|
| 摘要: |
| 姜黄素是一种天然的多酚类化合物，广泛存在于包括姜黄在内的多种草本植物中。它是一种天然的抗氧剂，具有许多的药理活性，安全有效，尤其是抗肿瘤作用受到广泛的关注。但由于姜黄素的水中溶解度差、光降解、化学不稳定以及生物利用度低等问题限制了其在临床的广泛应用。因此，需要开发适当的给药系统来解决这一问题。本文综述了近年来姜黄素纳米制剂在肿瘤治疗中的研究进展，重点阐述了其抗肿瘤纳米制剂的种类及其在细胞和动物实验中的应用，为进一步的研发提供依据。 |
| 关键词: 姜黄素 抗肿瘤 生物利用度 纳米制剂 |
| DOI：10.13748/j.cnki.issn1007-7693.2019.21.020 |
| 分类号:R285.5 |
| 基金项目:国家自然科学基金项目（81703709，81703425）；辽宁省科技厅博士科研启动基金项目（201601186）；中国博士后科学基金资助项目（2018M641716） |
|
| Research Progress of Curcumin Nano-preparations in Tumor Therapy |
|
CHEN Fen1, YANG Yue2, ZHANG Ling3, JIA Lianqun1, PAN Weisan2
|
|
1.Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China;2.Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;3.The First Affiliated Hospital of China Medical University, Shenyang 110001, China
|
| Abstract: |
| Curcumin is a natural polyphenolic compound, which widely exists in many herbs including curcuma. It is a natural antioxidant possessing excellent pharmacological activities, safety and effectiveness, especially its anti-tumor effect has been widely concerned. Its potential in clinical uses, however, are hindered by poor water solubility, photodegradation, chemical instability as well as low bioavailability. Therefore, it is necessary to develop appropriate drug delivery systems to solve the above issue. In this paper, the recent progress of curcumin nano-preparations in cancer therapy is introduced. The types of anti-tumor nano-preparations of curcumin and their applications in cell and animal experiments are emphasized, which will provide the basis for further research and development. |
| Key words: curcumin anti-tumor bioavailability nano-preparations |
