R语言计算药动学参数及生物等效性分析

吴正宇; 方文韬; 栾迪; 丁言运; 杨哲; 赵亚男<sup>*</sup>

引用本文:	吴正宇,方文韬,栾迪,丁言运,杨哲,赵亚男.R语言计算药动学参数及生物等效性分析[J].中国现代应用药学,2020,37(3):308-313.
	WU Zhengyu,FANG Wentao,LUAN Di,DING Yanyun,YANG Zhe,ZHAO Yanan.Pharmacokinetic Parameters Calculation and Bioequivalence Analysis by R Software[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(3):308-313.

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R语言计算药动学参数及生物等效性分析
吴正宇¹, 方文韬², 栾迪¹, 丁言运¹, 杨哲¹, 赵亚男^2,3
1.皖南医学院研究生学院, 安徽芜湖 241001;2.安徽医健领航医药科技有限公司, 合肥 230031;3.皖南医学院第一附属医院弋矶山医院, 安徽芜湖 241001

摘要:

目的使用R语言计算非房室模型药动学参数，并进行生物等效性分析。方法使用R语言中"NonCompart"包进行非房室模型药动学参数的计算。使用"nlme"包建立线性混合效应模型，进行多因素方差分析。使用"PowerTOST"包计算90%置信区间。将结果与Phoenix WinNonlin 6.4软件的计算结果对比。结果联合使用R包进行非房室模型药动学参数的计算与生物等效性分析的结果与Phoenix WinNonlin 6.4软件计算结果一致。结论可以通过R语言实现非房室模型药动学参数的计算与生物等效性分析，且结果可靠。

关键词: R语言药动学生物等效性

DOI：10.13748/j.cnki.issn1007-7693.2020.03.010

分类号:R917

基金项目:皖南医学院弋矶山医院第二周期学术带头人（YR201611）

Pharmacokinetic Parameters Calculation and Bioequivalence Analysis by R Software

WU Zhengyu¹, FANG Wentao², LUAN Di¹, DING Yanyun¹, YANG Zhe¹, ZHAO Yanan^2,3

1.Graduate School, Wannan Medical College, Wuhu 241001, China;2.Anhui Yijian Leading Medical Techology Co., Ltd., Hefei 230031, China;3.Yijishan Hospital of Wannan Medical College, Wuhu 241001, China

Abstract:

OBJECTIVE To calculate the pharmacokinetic parameters of non-compartmental models and analysis bioequivalence by use R software. METHODS The pharmacokinetic parameters of the non-compartmental model were calculated by the "NonCompart" package in the R software. A linear mixed-effects model was built using the "nlme" package for multivariate analysis of variance. Use the "PowerTOST" package to calculate the 90% confidence interval of geometric mean ratio. The results was compared with the Phoenix WinNonlin 6.4 software. RESULTS The results of pharmacokinetic parameters of the non-compartmental model and bioequivalence analysis by using the R software were consistent with result which calculated by Phoenix WinNonlin 6.4 software. CONCLUSION The pharmacokinetic parameters of non-compartmental model calculation and bioequivalence analysis can be achieved by R software and the result is reliable.

Key words: R software pharmacokinetic bioequivalence