当归挥发油及其苯酞类成分对平滑肌作用的研究进展

Advances in Research on Effects of the Essential Oil of Angelicae Sinensis Radix and Its Phthalide Constituents on Smooth Muscle

关键词:  功效  当归  挥发油  苯酞类  藁本内酯  丁苯酞  平滑肌

Key words:  function  essential oil  Angelicae Sinensis Radix  phthalide  ligustilide  butylphthalide  smooth muscle

摘要:

目的 基于功效综述当归挥发油及其苯酞类成分对平滑肌的作用。方法 通过检索CNKI、维普、PubMed及Web of Science数据库，筛选出相关的35篇文献进行综述，全面总结当归挥发油及其苯酞类成分对平滑肌的作用及其与当归功效之间的关系。结果 当归挥发油及其中藁本内酯、丁苯酞对平滑肌具有明显的药理活性，上述药理作用与当归功效有密切的关系。结论 当归挥发油及其苯酞类成分的药理活性及其与功效之间的关系研究，为其治疗心脑血管疾病、妇科疾病、呼吸系统疾病及消化系统疾病提供了理论依据，为当归及其有效组分的临床应用、研发调节平滑肌舒缩功能新药提供新的思路。

Abstract:

OBJECTIVE To review effects of the essential oil of Angelicae Sinensis Radix and its phthalide constituents on smooth muscle based on function. METHODS By searching CNKI, VIP, PubMed and Web of Science databases, 35 related literatures were screened out for review, and the effects of essential oil from Angelicae Sinensis Radix and its phthalides were summarized comprehensively. RESULTS The essential oil from Angelicae Sinensis Radix and its ligustilide and butylphthalide had obvious pharmacological activity on smooth muscle. The above pharmacological effects were closely related to the efficacy of Angelicae Sinensis Radix. CONCLUSION Study on the relationship of pharmacological activities and their functions between the essential oil from Angelicae Sinensis Radix and its phthalide components provides a theoretical foundation for the treatment of cardiovascular and cerebrovascular diseases, gynecological diseases, respiratory diseases and digestive diseases, and a new idea for the clinical application of Angelicae Sinensis Radix and its effective components and the research and development of new drugs to regulate the smooth muscle relaxation and contraction.