分区生存模型在药物经济学评价中的应用简介及实例解析

Introduction of Partitioned Survival Model in Pharmacoeconomics Evaluation and Case Analysis

关键词:  药物经济学  分区生存模型  Markov模型  敏感度分析  个体患者数据

Key words:  pharmacoeconomics  partitioned survival model  Markov model  sensitivity analysis  individual patient data

摘要:

目的 阐述分区生存模型的概念和基本构建方法，为中国转移性肿瘤疾病药物经济学评价的进一步研究提供参考。方法 结合转移性肾细胞癌治疗方案药物经济学评价实例，阐述分区生存模型在药物经济学评价中的应用及构建方法。结果 转移性肾细胞癌的自然转归符合分区生存模型基本原理，模型可划分为3种互不相容的生存状态，个体患者数据重建、生存分布函数参数的计算及各周期各状态患者人数的计算是建模的关键。结论 分区生存模型适用于转移性肿瘤疾病的药物经济学评价。

Abstract:

OBJECTIVE To introduce the basic concepts and construction method of partitioned survival model aimed at providing methodological reference for the further study of health economic evaluation of metastatic cancer in China. METHODS The application and construction method of partitioned survival model in pharmacoeconomics were described with the example of economic evaluation of the treatments of metastatic renal cell carcinoma. RESULTS The natural outcome of metastatic renal cell carcinoma conformed to the basic principle of the partitioned survival model. The model could be divided into three incompatible living states. The keys to modelling included reconstruction of individual patients data, estimation of the parameters of survival distributions, and estimation of the number of patients in each state of each cycle. CONCLUSION The partitioned survival model is suitable for health economic evaluation of treatments of metastatic cancer.