基于关联规则的中药治疗过敏性鼻炎用药规律分析

Analysis of Drug Use Law of Traditional Chinese Medicine for Allergic Rhinitis Based on Association Rules

关键词:  过敏性鼻炎  关联规则  用药规律

Key words:  allergic rhinitis  association rules  medication law

摘要:

目的 探讨中药治疗过敏性鼻炎（allergic rhinitis，AR）的用药规律。方法 以"中药"和"过敏性鼻炎"为主题词，搜索中国知网、万方数据和维普中文期刊（2010年1月-2019年1月）相关期刊文献，收集文献记载的方剂，建立数据库，进行统计分析。使用Excel 2013、SPSS Modeler 14.1、SPSS Statistics 19.0统计软件对纳入的中药进行关联规则分析和因子分析。结果 纳入符合标准的方剂147篇，共含中药175味，频数共计1 427次。在纳入的175味中药内，频数≥ 5的中药共57种；功效分类中，以解表药和补虚药最为常见，占比高达72.84%；药性药味中，以辛温药居多；归经分类中，以肺经、脾经和胃经居多。关联规则分析中发现关联强度最高的药对组合为10种，因子分析中提取6个公因子。结论 AR的中医治疗用药以解表药为主，且多与补虚药同用。

Abstract:

OBJECTIVE To explore the medication rule of traditional Chinese medicine in the treatment of allergic rhinitis (AR). METHODS Took "traditional Chinese medicine" and "allergic rhinitis" as subject headings, this paper searched the relevant periodical literature of CNKI, Wanfang Data and VIP Chinese periodical service platform(January 2010 to January 2019), collected the prescriptions recorded in the literature, established a database and carried out statistical analysis. Used Excel 2013, SPSS Modeler 14.1 and SPSS Statistics 19.0 statistical software, the association rule analysis and factor analysis were carried out on the included traditional Chinese medicines. RESULTS One hundred and forty seven prescriptions conforming to the standard were included, included 175 Chinese medicines with a total frequency of 1 427 times. Among the 175 Chinese medicines included, there were 57 kinds of Chinese medicines with frequency ≥ 5. Among the efficacy categories, drugs for relieving exterior syndrome and deficiency-nourishing were the most common, accounting for 72.84%. The pungent and warm drugs were the most common drugs in the medicinal flavor. Classification of meridian tropism included lung meridian, spleen meridian and stomach meridian. In association rule analysis, 10 combinations of drug pairs with the highest association intensity were found, and 6 common factors were extracted from factor analysis. CONCLUSION AR is mainly treated by relieving exterior syndrome and combines with deficiency-tonifying drugs.