鱼腥草颗粒联合头孢丙烯片治疗急性扁桃体炎的疗效

Clinical Efficacy of Houttuynia Granules Combined with Cefprozil Tablets in Treatment of Patients with Acute Tonsillitis

关键词:  急性扁桃体炎  联合治疗  临床疗效  炎症因子  免疫功能

Key words:  acute tonsillitis  combined therapy  clinical efficacy  cytokines  immune function

摘要:

目的 观察鱼腥草颗粒联合头孢丙烯片治疗急性扁桃体炎患者的临床疗效，分析其对患者炎症因子及免疫功能的影响。方法 选取嘉兴市中医医院2018年1~11月确诊为急性扁桃体炎患者240例，以随机数表法均分为治疗组和对照组。治疗组服用鱼腥草颗粒与头孢丙烯片，对照组仅服用头孢丙烯片。治疗3 d后，分析2组的临床效果及治疗总有效率；比较2组治疗前后血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、干扰素-β（IFN-β）水平及外周血CD4⁺、CD8⁺ T淋巴细胞和CD4⁺/CD8⁺水平。结果 治疗组体温恢复正常、扁桃体肿大及咳嗽持续时间分别为（1.84±0.23），（1.96±0.36），（2.17±0.43）d，均显著少于对照组（P<0.01），且总有效率为89.2%，显著高于对照组（P<0.01）。治疗组IL-6、TNF-α、IFN-β水平较治疗前及对照组显著降低（P<0.05）。治疗组外周血CD4⁺、CD8⁺水平与CD4⁺/CD8⁺值较治疗前及对照组显著提高（P<0.05）。结论 鱼腥草颗粒联合头孢丙烯片治疗能明显缩短急性扁桃体炎病程，改善患者临床症状与炎症反应，提高免疫功能。

Abstract:

OBJECTIVE To observe the clinical efficacy of Houttuynia granules combined with Cefprozil tablets in the treatment of patients with acute tonsillitis, and to analyze its effects on cytokines and immune function. METHODS The 240 patients with acute tonsillitis were diagnosed definitely from January to November 2018 in Jiaxing Hospital of TCM. The patients were divided into treatment group and control group by random number table method. The treatment group was treated with Houttuynia granules and Cefprozil tablets, while the control group was only treated with Cefprozil tablets by oral. After 3 days of treatment, the clinical efficacy and total treatment efficiency were analyzed. The expressions of serum interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) and interferon-β(IFN-β), and peripheral blood CD4⁺, CD8⁺ T lymphocytes and CD4⁺/CD8⁺ levels were compared before and after treatment. RESULTS In the treatment group, the time of body temperature recovery, tonsil swelling and cough duration was (1.84±0.23), (1.96±0.36), (2.17±0.43)d, respectively, which were significantly less than the control group(P<0.01). The total treatment efficiency was 89.2%, it was significantly higher than that of the control group(P< 0.01). The levels of serum cytokines IL-6, TNF-α and IFN-β in the treatment group were significantly lower than those of before treatment and the control group(P<0.05). The CD4⁺, CD8⁺ levels and CD4⁺/CD8⁺ values in the peripheral blood of the treatment group were significantly higher than those of before treatment and the control group(P<0.05). CONCLUSION The combination Houttuynia granules with Cefprozil tablets can significantly shorten the clinical course of acute tonsillitis, ameliorate clinical symptoms and inflammatory damage, and improve immune function.