西替利嗪联合布地奈德对支气管哮喘患儿疗效及血清TGF-β1、MCP-1、SDF-1水平的影响

Efficacy of Cetirizine Combined with Budesonide on Children with Bronchial Asthma and its Effects on Levels of Serum TGF-β1, MCP-1 and SDF-1

关键词:  小儿支气管哮喘  西替利嗪  布地奈德  转化生长因子β₁  单核细胞趋化蛋白-1  基质细胞衍生因子-1

Key words:  bronchial asthma in children  cetirizine  budesonide  transforming growth factor-β₁  monocyte chemoattractant protein-1  stromal-derived factor-1

摘要:

目的 研究西替利嗪联合布地奈德（budesonide，BUN）对支气管哮喘患儿治疗效果及血清转化生长因子β₁（TGF-β₁）、单核细胞趋化蛋白-1（MCP-1）、基质细胞衍生因子-1（SDF-1）水平的影响。方法 将94例急性发作期哮喘患儿随机均分为观察组（西替利嗪联合BUN，n=47）和对照组（BUN，n=47）进行治疗，疗程7 d，比较2组治疗效果、临床症状、肺功能指标及血清TGF-β₁、MCP-1、SDF-1水平变化。结果 观察组和对照组治疗有效率分别为95.74%和82.98%（P<0.05）；观察组咳嗽、憋喘症状及哮鸣音、湿罗音等体征消失时间少于对照组（P<0.05）；治疗后，2组患儿第1秒用力呼气容积（FEV₁）、FEV₁占预计值百分比（FEV₁%）及呼气峰值流速（PEF）均明显升高（P<0.05），且观察组FEV₁、FEV₁%及PEF高于对照组（P<0.05）；治疗后，2组血清TGF-β₁、MCP-1及SDF-1水平明显降低（P<0.05），且观察组血清TGF-β₁、MCP-1及SDF-1水平低于对照组（P<0.05）。结论 西替利嗪联合BUN治疗哮喘患儿可有效降低血清TGF-β₁、MCP-1及SDF-1表达水平，减轻呼吸道炎症反应，从而改善患儿症状，提高治疗效果。

Abstract:

OBJECTIVE To study the effects of cetirizine combined with budesonide(BUN) on treatment and levels of serum transforming growth factor-β₁(TGF-β₁), monocyte chemoattractant protein-1(MCP-1) and stromal-derived factor-1(SDF-1) in children with bronchial asthma. METHODS Ninety four cases of children with acute episode of asthma were randomly and evenly divided into observation group(cetirizine combined with BUN, n=47) and control group(BUN, n=47), and they were treated for 7 d. The treatment effects, clinical symptoms, pulmonary function indexes and levels of serum TGF-β₁, MCP-1 and SDF-1 were compared between the two groups. RESULTS The effective rate of treatment in observation group and control group were 95.74% and 82.98% respectively(P<0.05). The disappearance times of signs of cough, asthmatic symptoms, wheezing and wet rales in observation group were less than those in control group(P<0.05). After treatment, the forced expiratory volume in 1 second(FEV₁), the percentage of FEV₁ in predicted value(FEV₁%) and peak expiratory flow(PEF) were significantly increased in the two groups(P<0.05), and the levels of FEV₁, FEV₁% and PEF in observation group were higher than those in control group(P<0.05). After treatment, the levels of serum TGF-β₁, MCP-1 and SDF-1 were significantly decreased in the two groups(P<0.05), and the levels in observation group were lower than those in control group(P<0.05). CONCLUSION Cetirizine combined with BUN for asthmatic children can effectively reduce the expression levels of serum TGF-β1, MCP-1 and SDF-1, and relieve the respiratory tract inflammation, thereby improving the symptoms and treatment effects.