二甲双胍联合化疗药物抗肿瘤的研究进展

Research Progress of Metformin Combined and Chemotherapeutics in Anti-tumor

关键词:  二甲双胍  肿瘤  联合治疗  抗肿瘤机制  临床研究

Key words:  metformin  tumor  combination therapy  anti-tumor mechanism  clinical research

摘要:

二甲双胍作为治疗2型糖尿病的一线降糖药，不仅具有降糖作用，还可以对多种肿瘤起到防治作用，包括乳腺癌、肺癌、肝癌、子宫内膜癌、结直肠癌、胰腺癌、前列腺癌等。近年来，越来越多的研究倾向于将二甲双胍与临床中常用的化疗药物联合，从而使化疗药物增效减毒并提高患者生存率以及改善预后。本文主要对二甲双胍联合化疗药物抗肿瘤的作用机制及其在临床研究中的应用展开综述。

Abstract:

Metformin is a first line therapeutic agent that has been used to treat type Ⅱ diabetes mellitus, it also has been reported to be a potential anticancer drug which have cancer prevention effects or synergistic effects with chemotherapeutics against various cancers including breast cancer, lung cancer, liver cancer, endometrial cancer, colorectal cancer, and so on. In recent years, numerous studies tend to combine metformin with chemotherapeutics to achieve a significant anti-tumor effect with lower systemic toxicity and to improve survival and prognosis of the patients. In this review, the synergistic anticancer mechanisms of metformin combined with chemotherapeutics and its application in clinical research were summarized.